Abstract
Decreased bone mineral density (BMD) has been documented frequently in female patients with schizophrenia receiving antipsychotic therapy with potent dopamine D(2) antagonists, but there has been much less coverage of this issue in male patients with schizophrenia despite the fact that older males who sustain osteopenia-related hip fractures have subsequently greater mortality than females. A Medline search was performed for the years 1966-2004 using the following search terms: "osteopenia or osteoporosis or bone density or bone mineral density," combined with "schizophrenia or psychosis or antipsychotic." The search yielded 8 studies which provided data on bone mineral density in male patients with schizophrenia, of which 2 were case reports, and 3 were controlled studies. Hormonal measures were present in 6 studies. In every study where such information was provided, the patients with schizophrenia had significantly lower BMD than nonschizophrenic controls or population norms, with the prevalence of osteopenia ranging from 40-72%. Low BMD and corresponding osteopenia or osteoporosis may be a highly prevalent but significantly underdiagnosed medical condition among male schizophrenia patients. Psychiatrists should consider BMD...Continue Reading
References
Dec 1, 1989·Biological Psychiatry·N J DelvaE R Yendt
Jan 1, 1987·Neuropsychobiology·T HiguchiT Yamauchi
Sep 1, 1995·Psychosomatic Medicine·U HalbreichR Rosan
Sep 1, 1996·Biological Psychiatry·G AbrahamC Verghese
Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A BarondessS E Schlaen
Jul 25, 1997·Schizophrenia Research·A M CrawfordG D Tollefson
Nov 10, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O CohenI Vered
Jun 6, 2000·The American Journal of Clinical Nutrition·D R Wagner, V H Heyward
Nov 30, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Tannirandorn, S Epstein
Dec 20, 2000·Schizophrenia Research·D R Combs, C Advokat
Feb 15, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
Nov 5, 2002·Schizophrenia Research·George AbrahamRichard C Josiassen
Nov 12, 2002·The International Journal of Neuroscience·Mustafa BiliciUner Tan
Mar 26, 2003·Psychoneuroendocrinology·U NaidooA Klibanski
Aug 26, 2003·The Journal of Clinical Psychiatry·Daniel BeckerMordechai Weiss
Aug 29, 2003·The American Journal of Psychiatry·George AbrahamRichard C Josiassen
Sep 18, 2003·Psychiatrische Praxis·Mirijam Fric, Gerd Laux
Feb 12, 2004·Journal of Psychopharmacology·Anna Maria Meaney, Veronica O'Keane
Apr 23, 2004·International Clinical Psychopharmacology·Mike Lean, Goedele De Smedt
Jun 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·A M MeaneyV O'Keane
Aug 3, 2004·The American Journal of Psychiatry·Stephen R MarderSteven Shon
Jun 2, 2005·Schizophrenia Research·David Lehman, Jonathan M Meyer
Citations
Oct 7, 2008·International Psychogeriatrics·Brendon StubbsCamilla Haw
Jan 3, 2009·BMC Musculoskeletal Disorders·Jenn-Huei RennPesus Chou
Dec 31, 2008·Pharmacotherapy·Jolene R BostwickVicki L Ellingrod
Jul 5, 2016·Frontiers in Pharmacology·Stefania SchiavoneLuigia Trabace
Sep 17, 2015·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Bruna Andrade E SilvaMarco T de Mello
Oct 12, 2011·Neuroendocrinology·Mirjana DoknicVera Popovic
Jun 23, 2011·Journal of Clinical Psychopharmacology·Do-Un JungJoo-Cheol Shim
Jun 6, 2008·Current Opinion in Rheumatology·Juliette Allport
Dec 20, 2007·The Journal of ECT·Chittaranjan AndradeNagendra M Singh
Jul 16, 2008·Journal of Clinical Psychopharmacology·James M BoltonWilliam D Leslie
Dec 31, 2010·Journal of Clinical Psychopharmacology·James M BoltonWilliam D Leslie
Aug 12, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Abrahamsen, K Brixen
Mar 27, 2009·CNS Drugs·Pierre ThomasMichael Riedel
Jul 22, 2014·Acta Psychiatrica Scandinavica·B StubbsD Vancampfort
Feb 12, 2013·Clinical Schizophrenia & Related Psychoses·Bruce J KinonJayanthi Jacob
Apr 22, 2021·CNS Drugs·Frank M C BesagIffah Salim