Bone mineral density in patients with early rheumatoid arthritis treated with corticosteroids

Clinical Rheumatology
George S Habib, Shehadeh Haj

Abstract

The aim of this study was to evaluate the bone mineral density (BMD) in patients with early rheumatoid arthritis (RA) prior to and 6 months after adding low-dose corticosteroid (CS) treatment. Adult patients (>21 years old) with early RA (symptom duration <1 year) and severe joint pain under maximal dose of nonsteroidal anti-inflammatory drugs (NSAIDS) were started on low-dose prednisone (10 mg/day). Patients were evaluated after 1, 3, and 6 months. Disease activity measures including swollen and tender joint count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were documented, and the dose of prednisone was adjusted according to the level of pain at each visit. BMD of the femoral neck (FN) and lumbar spine (LS) was measured using dual energy X-ray absorptiometry prior to and 6 months after starting CS treatment. Calcium supplements, vitamin D, bisphosphonates, or hormonal therapy that may affect BMD were not permitted during the study. Twenty patients were eligible and 16 completed the study; 75% were female. The mean age was 47.2+/-12 years and mean duration of symptoms was 7+/-2 months. The mean BMD at the FN prior to and 6 months after starting CS treatment were 0.8080 g/cm(2)+/-0.1145 and 0.8242 g/cm(2...Continue Reading

References

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Citations

Mar 25, 2010·Arthritis Research & Therapy·Monica IbañezIsidoro González-Alvaro
Aug 9, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E S Leib, R Winzenrieth
Jun 10, 2008·Clinics in Chest Medicine·Robert P BaughmanRonald M du Bois
Apr 18, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Véronique Breuil, Liana Euller-Ziegler
Jan 10, 2018·Calcified Tissue International·Melek Güler-YükselWillem F Lems
Nov 18, 2008·Journal of Pediatric Hematology/oncology·Zühal Keskin YildirimCahit Karakelleoğlu
Mar 17, 2019·The Journal of Rheumatology·Sandrine Malochet-GuinamandMaxime Dougados
Jan 19, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N GuañabensUNKNOWN OsteoResSer Working Group of the Spanish Society of Rheumatology

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