Bone mineral density in Turner's syndrome and the influence of pubertal development

Acta Paediatrica
Montasser Nadeem, Edna F Roche

Abstract

To describe bone mineral density at the lumbar spine in a group of girls with Turner's syndrome and determine its relation to pubertal development. Girls with Turner's syndrome aged over 12 years were invited to participate in the study. All participants underwent auxology, pubertal assessment and laboratory evaluation. Bone mineral density was estimated by dual-energy X-ray absorptiometry. Bone mineral apparent density was then calculated, and the results were compared with age-matched Dutch reference data. We studied 32 girls with Turner's syndrome, mean (SD) [range] age 16.7 (2.6) [12.4-20.2] years and height 148.3 (9.0) [126-159.2] cm. Bone mineral apparent density lumbar spine values were -0.87 SD, significantly lower than in the reference population (p <0.001). Bone mineral apparent density values were positively and significantly associated with breast Tanner stages and postmenarcheal status, but not spontaneous puberty. However, no significant association was found between bone mineral apparent density and karyotype, growth hormone or timing of oestrogen therapy. Girls with Turner's syndrome have lower bone mineral apparent density values at the lumbar spine, even after correcting for size, compared with an age- and sex...Continue Reading

References

Jan 1, 1987·Acta Paediatrica Scandinavica. Supplement·H M HoeyL A Cox
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A Kanis
Apr 1, 1993·The Journal of Clinical Endocrinology and Metabolism·E K NeelyL K Bachrach
Dec 3, 1999·Clinical Endocrinology·K Landin-WilhelmsenL Wilhelmsen
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A CarrascosaE Vicens-Calvet
Aug 31, 2002·Journal of Bone and Mineral Metabolism·Aline M G CostaGil Guerra
Sep 24, 2002·Archives of Disease in Childhood·I M van der SluisS M P F de Muinck Keizer-Schrama
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gautam KhastgirJade W M Chow
Sep 12, 2003·The American Journal of Medicine·Vladimir K BakalovCarolyn A Bondy
Nov 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Selma Cvijetić, Mirko Korsić
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Vladimir K BakalovCarolyn A Bondy
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Wolfgang HöglerChristopher T Cowell
May 23, 2006·Archives of Disease in Childhood·M D C DonaldsonD B Dunger
Aug 31, 2006·The Journal of Clinical Endocrinology and Metabolism·Mim AriCarolyn A Bondy
Oct 19, 2006·The Journal of Clinical Endocrinology and Metabolism·Carolyn A Bondy, UNKNOWN Turner Syndrome Study Group
May 19, 2009·European Journal of Endocrinology·Line CleemannClaus H Gravholt
Feb 6, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C R HolroydE M Dennison
Sep 10, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P PitukcheewanontG Costin
Nov 6, 2012·The Journal of Clinical Endocrinology and Metabolism·Annemieke J LemAnita C S Hokken-Koelega
Feb 22, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Montasser Nadeem, Edna F Roche

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Citations

May 20, 2017·Climacteric : the Journal of the International Menopause Society·H H NguyenA Vincent
Aug 11, 2018·Climacteric : the Journal of the International Menopause Society·S ShahA J Vincent
Jul 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Hanh H NguyenAmanda Vincent
Aug 17, 2019·American Journal of Medical Genetics. Part a·Angela E LinClaus H Gravholt
Nov 11, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sarar MohamedHilary M C V Hoey
Sep 4, 2021·Endocrine Reviews·Peter R EbelingFrances Milat

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