Bone mineral density, sex hormones, and long-term use of neuroleptic agents in men.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
E J KeelyC Faiman

Abstract

To study the prevalence and severity of bone mineral loss and its relationship to sex hormone levels in men on long-term neuroleptic therapy. Sixteen men with schizophrenia who were from 19 to 62 years old and had taken neuroleptic medication for 1 to 30 years had bone mineral density (BMD) of the lumbar spine and proximal femur measured by dual-energy x-ray absorptiometry. Results were compared with those from 16 age-matched control subjects. Serum testosterone, sex hormone-binding globulin, free testosterone index (FTI), prolactin, and pituitary gonadotropins were assayed and compared with age-matched Red Cross blood donor controls (N = 23 to 90 for the various assays). At the lumbar spine and at two of the three sites in the proximal femur (trochanter and Ward's triangle but not femoral neck), the BMD was lower in patients than in controls. A statistically significant increase in prolactin and sex hormone-binding globulin and a significantly decreased luteinizing hormone and FTI were found in the treated versus the control group. In the patient group, a significant inverse relationship existed between age and BMD at all sites. Lumbar spine density was related directly to FTI (r = 0.607; P=0.05) and inversely to duration of t...Continue Reading

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Citations

Apr 6, 1999·Schizophrenia Research·R A Dickson, W M Glazer
Jun 30, 2012·Current Opinion in Psychiatry·Taishiro KishimotoChristoph U Correll
Mar 8, 2011·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Marc DE HertStefan Leucht
Sep 5, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E AkC Kısa
Jun 30, 2005·Journal of Psychiatric Practice·Uriel Halbreich, Linda S Kahn
Oct 9, 2007·Acta Psychiatrica Scandinavica·S LeuchtN Sartorius
Apr 23, 2004·International Clinical Psychopharmacology·Mike Lean, Goedele De Smedt
Feb 12, 2013·Clinical Schizophrenia & Related Psychoses·Bruce J KinonJayanthi Jacob
Jan 22, 2011·Psychiatry Investigation·Tae-Young LeeHyung-Seok So

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