Bone mineral mass in males and females with and without Down syndrome

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Fatima BaptistaLuis B Sardinha

Abstract

Previous bone comparison studies between subjects with and without Down syndrome (DS) were performed using bone mineral density (BMD) as the dependent variable, and mainly focused on lumbar spine region. The purpose of this study was to compare bone mineral mass adjusted for bone and body size, in limbs, lumbar spine, and femoral neck between males and females with and without DS. Subjects were 66 females (33 with DS) and 68 males (34 with DS) aged 14-40 years. Analysis of covariance (ANCOVA) was used to analyze the main and interaction effects of gender and condition on bone mineral mass. For this purpose, adjusted bone mineral content (BMC) (for bone area, height, and age), volumetric bone mineral density (vBMD) (for age), and composite indices of femoral neck strength (for age), were used as the dependent variables, corrected additionally for body composition variables selected by regression analysis. ANCOVA revealed lower lumbar spine vBMD in DS than in control subjects with (-5%, P = 0.013), or without body weight adjustments (-6%, P = 0.003). In femoral neck, the mean of each strength measure was also lower in DS than in control subjects. Mean differences between groups were, with and without additional adjustments for fa...Continue Reading

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