Bone mineralisation adjacent to cemented and uncemented acetabular cups: analysis by [18F]-fluoride-PET in a randomised clinical trial.

Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Gösta UllmarkEnn Maripuu

Abstract

We present a randomised clinical trial using F-PET/CT to analyse new bone metabolic mineralisation adjacent to acetabular cups following total hip arthoplasty (THA). THA was performed on 26 patients (26 cases) with hip OA. Patients with hip osteoarthritis (OA) were randomly assigned to operations with cemented or uncemented acetabular components. The contralateral, healthy acetabulum was used as referent for normal bone metabolism. The patients were analysed with radiography, clinical scoring, and F-PET/CT preoperatively, and at 6 weeks and 6 months postoperatively. No major complications were recorded, and clinical results were good in all patients. Radiography showed all cups to be stable. The bone-forming activity, as measured by F-PET/CT, was quantified as standardised uptake values (SUV). The mean SUV was 4.6 (6 weeks) and 3.5 (6 months) around the uncemented cups, and 4.8 and 4.0, respectively, for the cemented cups. Normal healthy bone metabolism in the referent was 2.8 and 2.7 SUV at 6 weeks and 6 months, respectively. P < 0.01 for the cemented group at 6 weeks and 6 months, for the uncemented group only at 6 weeks. An acetabulum affected by OA has elevated SUV activity. Both cemented and uncemented cups had elevated bo...Continue Reading

Associated Clinical Trials

References

May 15, 2003·Current Rheumatology Reports·H Clarke Anderson
Jan 18, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Stefan ToegelMarkus Mitterhauser
Apr 28, 2007·Acta Orthopaedica·Gösta UllmarkOlle Nilsson
Dec 14, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frederick D GrantS Ted Treves
May 1, 2009·Acta Orthopaedica·Gösta UllmarkOlle Nilsson
Feb 8, 2011·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Gösta UllmarkJens Sörensen
May 2, 2012·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Gösta UllmarkOlle Nilsson
Dec 7, 2018·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Gösta UllmarkOlle Nilsson

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Citations

Feb 17, 2021·PET Clinics·William Y RaynorMona-Elisabeth Revheim

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Methods Mentioned

BETA
total hip arthoplasty
total hip arthroplasty

Clinical Trials Mentioned

NCT01623687

Software Mentioned

SAS

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