Bone morphogenetic protein-2 exhibits therapeutic benefits for osteonecrosis of the femoral head through induction of cartilage and bone cells

Experimental and Therapeutic Medicine
Chunhui WangDongsheng Zhou

Abstract

Osteonecrosis of the femoral head is an orthopedic disease caused by femoral head damage or insufficient blood supply, which leads to the death of bone cells and bone marrow. Osteonecrosis of the femoral head leads to changes in the structure of the femoral head, femoral head collapse and joint dysfunction. Bone morphogenetic protein-2 (BMP-2) exhibits beneficial effects on bone formation, repair and angiogenesis at the femoral head. In the present study, the therapeutic effects of recombinant human BMP-2 containing an Fc fragment (rBMP-2/Fc) were investigated on a steroid induced mouse model of osteonecrosis of the femoral head. Bone cell viability was used to determine the in vitro effects of rBMP-2/Fc. The therapeutic efficacies of rBMP-2/Fc on mice with osteonecrosis of the femoral head were evaluated using clinical arthritis scores. The expression levels of inflammatory factors in the mice were analyzed by reverse transcription-quantitative polymerase chain reaction. Histological analysis was used to evaluate the effects of rBMP-2/Fc on the femoral head. The results revealed that rBMP-2/Fc treatment significantly increased the IL-6, IL-10, vascular endothelial growth factor and macrophage colony-stimulating factor expressi...Continue Reading

References

Sep 1, 1988·Nihon Jibiinkoka Gakkai kaiho·M OkamotoK Furukawa
Jun 15, 2000·Clinical Orthopaedics and Related Research·Y OkuboT Iizuka
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 25, 2006·The Journal of Craniofacial Surgery·Ylker OzeçCesur Gümüş
Apr 13, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S RadkeN Schütze
Jun 23, 2006·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Hisanobu YonezawaSyoji Enomoto
Mar 27, 2007·Arthritis Research & Therapy·Rik J U Lories, Frank P Luyten
Jul 27, 2007·Alternatives to Laboratory Animals : ATLA·Gareth Davey, Zhihui Wu
Feb 2, 2008·Arthritis and Rheumatism·Michael J ElliotJames N Woody
Oct 22, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Barbara SegalKetan Patel
Sep 2, 2009·Clinical Oral Implants Research·João Paulo Mardegan IssaRubens Ferreira de Albuquerque
Sep 30, 2009·International Journal of Molecular Medicine·Lin YeWen G Jiang
Jan 1, 2010·Neurosurgery·Jayesh P ThawaniPaul Park
Oct 21, 2010·Cellular Signalling·Beth BragdonAnja Nohe
Oct 16, 2012·Journal of Pharmacy & Bioallied Sciences·Karuppanan P SasikumarJayaprakash S Gadagi
Jun 27, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Charalampos G Zalavras, Jay R Lieberman
Aug 15, 2014·Experimental and Therapeutic Medicine·Cheng WangShibi Lu
Sep 2, 2014·Arthritis Research & Therapy·Claire J GreenhillSimon A Jones
Jan 28, 2015·The Journal of the American Academy of Orthopaedic Surgeons·Dick van der JagtJay R Lieberman
May 27, 2015·Current Reviews in Musculoskeletal Medicine·Todd P PierceRonald E Delanois
Jun 6, 2015·Current Reviews in Musculoskeletal Medicine·Todd P PierceMichael A Mont
Feb 28, 2016·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Hajime MishimaNaoyuki Ochiai
Mar 24, 2016·American Journal of Physical Medicine & Rehabilitation·Yue Wen MaXiao Tong Yu
Apr 29, 2016·Nature Reviews. Rheumatology·Sarah Onuora
Apr 30, 2016·International Journal of Rheumatic Diseases·Danveer BhaduSaumya Ranjan Tripathy

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
ion exchange chromatography
gel filtration
electrophoresis
PCR
immunoprecipitation assay
protein assay
Infrared Imaging

Software Mentioned

Soft Imaging System
ImageJ
BandScan

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.