Bone Morphogenetic Protein 2 Promotes Human Trophoblast Cell Invasion by Inducing Activin A Production

Endocrinology
Hong-Jin ZhaoPeter C K Leung

Abstract

Bone morphogenetic protein (BMP) 2 and activin A belong to the TGF-β superfamily and are highly expressed in human endometrium and placenta. Studies have demonstrated that activin A and BMP2 play essential roles in the process of early embryo implantation by promoting human trophoblast cell invasion. However, whether activin A production can be regulated by BMP2 in human trophoblast cells remains unknown. The aim of our study was to determine the effects of BMP2 on activin A production and its role in human trophoblast invasion. Primary human extravillous trophoblast (EVT) cells were used as study models. BMP2 treatment significantly increased inhibin βA (INHBA) mRNA levels and activin A production without altering inhibin α and inhibin βB levels. BMP2-induced EVT cell invasion was attenuated by knockdown of INHBA. The increased INHBA transcription and activin A production by BMP2 were blocked by the type I receptor activin receptor (ACVR)-like kinase 2 (ALK2) and activin receptor-like kinase 3 (ALK3) inhibitor dorsomorphin homolog 1 (DMH-1). BMP2-induced INHBA upregulation was also inhibited by knockdown of type I receptor ALK3 or combined knockdown of type II receptors for BMP2 (BMPR2) and ACVR2A. Whereas BMP2 initiated both ...Continue Reading

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Citations

Oct 1, 2019·Biology of Reproduction·Enoch Appiah Adu-GyamfiYing-Xiong Wang
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hong-Jin ZhaoPeter C K Leung
Mar 19, 2020·Biomolecules·Susana M Chuva de Sousa LopesGudrun Valdimarsdottir
Sep 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin LuoPeter C K Leung
Jul 28, 2019·Biology of Reproduction·Kelsey M HirschiJuan A Arroyo
Oct 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Long BaiPeter C K Leung
Jan 23, 2021·Trends in Endocrinology and Metabolism : TEM·Yan LiPeter C K Leung
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Jiali YouYi-Min Zhu

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