Bone morphogenetic protein-2 used in spinal fusion with spinal cord injury penetrates intrathecally and elicits a functional signaling cascade

The Spine Journal : Official Journal of the North American Spine Society
Anton E DmitrievAviva J Symes

Abstract

The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) and its indications for spinal fusion continue to be expanded with recent reports citing spinal trauma application. However, there are no data establishing the effects of rhBMP-2 on the injured spinal cord. The purpose of this study was to evaluate the extent of bone morphogenetic protein (BMP)-specific intrathecal signaling after application to the spine at various time points after a spinal cord injury (SCI). This is an in vivo rat study using a combination of the dorsal hemisection SCI and the posterolateral arthrodesis animal models. Sixty-five female Sprague-Dawley rats underwent either a T9-T10 dorsal hemisection SCI (n=52) or laminectomy only (n=13). Spinal cord injury animals were further subdivided into four follow-up groups (n=13/group): 30 minutes, 24 hours, 7 days, and 21 days, at which time one of two secondary surgeries were performed: Eight rats per time point received either 43 microg of rhBMP-2 per side or sterile water control over T9-T11 on absorbable collagen sponges (ACSs). Animals were perfused after 24 hours, and spinal cords were immunohistochemically analyzed. Sections of the lesion were stained with BMP-specific pSmad 1, 5, 8 antibody ...Continue Reading

References

Sep 3, 1999·The Orthopedic Clinics of North America·H S SandhuH Parvataneni
Nov 27, 2001·Brain Research·T SetoguchiS Izumo
Jan 25, 2002·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·V J LeferinkH J ten Duis
Sep 30, 2003·Journal of Neuroscience Research·William D WhetstoneLinda J Noble-Haeusslein
Jan 22, 2004·Nature Reviews. Neuroscience·Jerry Silver, Jared H Miller
Feb 18, 2005·Journal of Biochemistry and Molecular Biology·Seok Hee Park
Dec 13, 2005·Nature Reviews. Neuroscience·Aimin Liu, Lee A Niswander
Dec 31, 2005·Journal of Neurosurgery. Spine·Alan T VillavicencioJeffrey Thramann
Aug 8, 2006·Biochemical and Biophysical Research Communications·Young Hwan AhnSoo Kyung Kang
Jan 2, 2007·The Spine Journal : Official Journal of the North American Spine Society·Steven D GlassmanJohn R Dimar
Apr 4, 2007·Journal of Neurotrauma·Jason T Maikos, David I Shreiber
May 12, 2007·The Journal of Biological Chemistry·Kouichiro GotoKeiji Miyazawa
May 29, 2007·The Spine Journal : Official Journal of the North American Spine Society·Kai-Uwe LewandrowskiRobert Calderon
Jul 11, 2007·Spine·Steven D GlassmanLeah Y Carreon
Jul 17, 2007·Biochemical and Biophysical Research Communications·Iichiro MatsuuraToshihide Yamashita
Aug 19, 2007·Annals of Neurology·Molly L FullerRobert H Miller
Nov 13, 2007·Journal of Occupational and Environmental Medicine·Chao SunAlan Ducatman
Nov 27, 2007·The Spine Journal : Official Journal of the North American Spine Society·David A WongKatherine Wong
Jan 29, 2008·Journal of Neurochemistry·Iichiro MatsuuraToshihide Yamashita
Nov 7, 2008·Journal of Neurotrauma·Peter E BatchelorDavid W Howells
Feb 5, 2009·Immunology·Jun Hyuk HongIsaac Yi Kim

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Citations

Nov 30, 2011·Molecular Neurobiology·Aquilino LanteroMaría A Hurlé
Jan 30, 2016·Journal of Neurosurgery. Spine·Timothy ChryssikosCharles A Sansur
Nov 30, 2011·The Spine Journal : Official Journal of the North American Spine Society·Peter C GersztenRichard J Nasca
Sep 20, 2011·The Spine Journal : Official Journal of the North American Spine Society·Elizabeth A SalisburyAlan R Davis
Sep 6, 2011·The Spine Journal : Official Journal of the North American Spine Society·Kristen E RadcliffAlexander R Vaccaro
Jul 7, 2011·The Spine Journal : Official Journal of the North American Spine Society·Eugene J CarrageeBradley K Weiner
Jul 7, 2011·The Spine Journal : Official Journal of the North American Spine Society·Anton E DmitrievAviva J Symes
Jul 6, 2010·The Spine Journal : Official Journal of the North American Spine Society·Steven D GlassmanLeah Y Carreon
Nov 21, 2013·Journal of Neurochemistry·Kendall MitchellAviva J Symes
Sep 30, 2014·The Spine Journal : Official Journal of the North American Spine Society·Haijun TianMichael D Daubs
Sep 25, 2016·The Spine Journal : Official Journal of the North American Spine Society·Michael H HeggenessShang-You Yang
Oct 30, 2016·The Spine Journal : Official Journal of the North American Spine Society·Shang-You YangMichael H Heggeness
Dec 20, 2016·Orthopedics·Daniel G KangRonald A Lehman
Jun 18, 2017·Journal of Cellular Biochemistry·Pedro Alvarez-UrenaElizabeth Olmsted-Davis
Dec 7, 2018·Critical Reviews in Food Science and Nutrition·Simona DraganConstantin Tudor Luca
Oct 20, 2012·Spine·V R Roopesh KumarAwdhesh Kumar Yadav
Dec 26, 2018·Critical Reviews in Food Science and Nutrition·Uwe GröberKlaus Kisters
Dec 29, 2011·The Journal of Bone and Joint Surgery. American Volume·Anton E DmitrievAviva J Symes
May 28, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ravi Kumar MamindlaBarada P Sahu

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