Bone morphogenetic protein 4 antagonizes hair cell regeneration in the avian auditory epithelium

Hearing Research
Rebecca M LewisJennifer S Stone

Abstract

Permanent hearing loss is often a result of damage to cochlear hair cells, which mammals are unable to regenerate. Non-mammalian vertebrates such as birds replace damaged hair cells and restore hearing function, but mechanisms controlling regeneration are not understood. The secreted protein bone morphogenetic protein 4 (BMP4) regulates inner ear morphogenesis and hair cell development. To investigate mechanisms controlling hair cell regeneration in birds, we examined expression and function of BMP4 in the auditory epithelia (basilar papillae) of chickens of either sex after hair cell destruction by ototoxic antibiotics. In mature basilar papillae, BMP4 mRNA is highly expressed in hair cells, but not in hair cell progenitors (supporting cells). Supporting cells transcribe genes encoding receptors for BMP4 (BMPR1A, BMPR1B, and BMPR2) and effectors of BMP4 signaling (ID transcription factors). Following hair cell destruction, BMP4 transcripts are lost from the sensory epithelium. Using organotypic cultures, we demonstrate that treatments with BMP4 during hair cell destruction prevent supporting cells from upregulating expression of the pro-hair cell transcription factor ATOH1, entering the cell cycle, and fully transdifferentiati...Continue Reading

References

Jun 24, 1988·Science·J T Corwin, D A Cotanche
Oct 1, 1987·Archives of Otolaryngology--head & Neck Surgery·R M CruzE W Rubel
Jun 29, 1995·Nature·D HenriqueD Ish-Horowicz
Feb 3, 1995·Science·S Chardin, R Romand
Jun 16, 1997·The Journal of Cell Biology·T HassonD P Corey
Jul 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H M SobkowiczS M Slapnick
Jun 12, 1999·Science·N A BerminghamH Y Zoghbi
Feb 8, 2000·The Journal of Comparative Neurology·J S Stone, E W Rubel
Jun 8, 2001·Neuron·N A BerminghamH Y Zoghbi
Dec 4, 2001·Mechanisms of Development·Y Kee, M Bronner-Fraser
Feb 21, 2003·Current Opinion in Neurobiology·Olivia Bermingham-McDonogh, Edwin W Rubel
Jun 19, 2003·Molecular and Cellular Neurosciences·Jianyong ShouWei Qiang Gao
Jul 23, 2003·Developmental Biology·Jeanette HyerTakashi Mikawa
Sep 17, 2004·Journal of Neuroscience Research·David W RobersonDouglas A Cotanche
Nov 16, 2004·Nature Neuroscience·Chad WoodsMatthew W Kelley
Aug 19, 2005·BMC Developmental Biology·Huawei LiStefan Heller
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer M JonesMatthew W Kelley
Feb 7, 2006·Developmental Biology·Cristina PujadesFernando Giraldez
Nov 11, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jon CafaroJennifer S Stone
Dec 26, 2006·Cardiovascular Research·Bram van WijkMaurice J B van den Hoff
Jun 9, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chandrakala PuligillaMatthew W Kelley
Sep 25, 2007·The International Journal of Developmental Biology·Jennifer S Stone, Douglas A Cotanche
Sep 19, 2009·Journal of Biochemistry·Kohei MiyazonoMasato Morikawa
Feb 19, 2010·Journal of the Association for Research in Otolaryngology : JARO·Jialin ShangJennifer Stone
May 5, 2010·Hearing Research·Douglas A Cotanche, Christina L Kaiser
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrés KamaidFernando Giráldez
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takahiro OhyamaAndrew K Groves
Mar 17, 2012·Cytokine & Growth Factor Reviews·Jing Guo, Gang Wu
May 1, 2012·Hearing Research·Rebecca M LewisJennifer S Stone
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael C KellyPing Chen
Jun 14, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tiantian CaiAndrew K Groves

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