Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1

Experimental Cell Research
T KnittelG Ramadori

Abstract

Bone morphogenetic protein-6 (BMP-6) is a member of the TGF-beta superfamily, which controls growth and differentiation during embryogenesis and acts as an osteoinductive factor in the adult organism. In order to gain further insights into the role of BMP-6, the present study analyzed the expression pattern of BMP-6 in adult rat tissues with special emphasis to the liver, since TGF-beta 1, another member of the TGF-beta superfamily, has been shown to play a fundamental role in liver physiology. Rat BMP-6-coding cDNAs were generated by homology cloning using RT-PCR and displayed 89.6 and 83.4% homology to mouse and human BMP-6, respectively. By Northern blotting BMP-6-specific transcripts 3.7 kb in size were detected in major amounts in lung and in minor quantities in spleen, kidney, heart, brain, and liver. Among the different hepatic cell populations tested BMP-6 expression was confined to nonparenchymal liver cells, namely rat hepatic stellate cells (HSC) and Kupffer cells (KC). During primary culture BMP-6 expression was increased in HSC but declined in KC. Interestingly, TGF-beta 1 stimulated BMP-6 expression of HSC especially at an early time point of culture, while interferon-gamma downregulated BMP-6 expression. The dete...Continue Reading

References

Dec 1, 1992·Experimental Cell Research·M OdenthalG Ramadori
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N S CunninghamA H Reddi
Oct 1, 1992·Gastroenterology·G RamadoriK H Meyer zum Büschenfelde
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S SchwöglerG Ramadori
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J A McGuireJ A Gustafsson
Mar 1, 1992·Trends in Genetics : TIG·V Rosen, R S Thies
Jun 1, 1992·Molecular Reproduction and Development·J M Wozney
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A J CelesteJ M Wozney
Sep 12, 1989·Nucleic Acids Research·V Barbu, F Dautry
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K LyonsR Derynck
Apr 10, 1987·Nucleic Acids Research·R DerynckA Van Tilburg
Apr 1, 1987·Journal of Hepatology·G RamadoriK H Meyer zum Büschenfelde
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·V DrozdoffW J Pledger
May 1, 1995·Pharmacology & Therapeutics·M Pinzani

❮ Previous
Next ❯

Citations

Nov 9, 2010·Expert Reviews in Molecular Medicine·Deepak DarshanGregory J Anderson
Apr 11, 2006·Nature Genetics·Jodie L BabittHerbert Y Lin
Apr 21, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Qi FengRobert E Fleming
Jul 4, 2007·The Journal of Clinical Investigation·Jodie L BabittHerbert Y Lin
Jul 6, 2014·Annual Review of Nutrition·Nermi L Parrow, Robert E Fleming
Jan 5, 2002·Expert Opinion on Investigational Drugs·K AzariJ O Hollinger
Mar 19, 2014·Frontiers in Pharmacology·Christal A Worthen, Caroline A Enns
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·J H ClementK Höffken
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H TamadaS Kitazawa
Nov 13, 2007·Digestive Diseases and Sciences·Manuela G NeumanGiuliano Ramadori
Mar 10, 1999·The American Journal of Physiology·M SimonH E Abboud
Dec 16, 2006·World Journal of Gastroenterology : WJG·Cui-Ping XuMaikel P Peppelenbosch
Jun 13, 2000·The Journal of Biological Chemistry·A F MillerM S Olson
Oct 11, 2014·International Orthopaedics·Martina PaukSlobodan Vukicevic
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gregory J Anderson
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bernhard SaileGiuliano Ramadori
Dec 14, 1999·The American Journal of Pathology·T KnittelG Ramadori
Apr 24, 2021·The American Journal of Pathology·Steven A Bloomer, Kyle E Brown
Jul 14, 2001·Molecular and Cellular Endocrinology·H ChangM M Matzuk
Dec 7, 2002·Seminars in Cell & Developmental Biology·Raza MalikHumphrey Hodgson
May 13, 2008·Neuroscience Letters·Hung-Bun LamJuei-Tang Cheng
Jan 29, 2016·Gastroenterology·Mark D KlevenAn-Sheng Zhang
Aug 26, 2011·Biochimica Et Biophysica Acta·Juxing Chen, Caroline A Enns

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.