Bone morphogenetic protein (RhBMP-2) as a substitute for iliac crest bone graft in multilevel adult spinal deformity surgery: minimum two-year evaluation of fusion

Spine
Daniel S MulconreyPeter S Rose

Abstract

Prospective, single center, nonblinded radiographic analysis of anterior and posterior adult spinal deformity fusions performed with bone morphogenetic protein (rhBMP-2). To determine the ability of rhBMP-2 to achieve multilevel spinal fusion in the deformity patient. No previous study has evaluated rhBMP-2 for multilevel adult spinal deformity fusion with 2-year results. We postulated fusion could be achieved without distant autogenous graft harvest. Prospective analysis was performed for 98 patients (308 levels; mean age, 51.4 years) who underwent multilevel anterior or posterior spinal fusion (PSF) with minimum 2-year follow-up (average, 2.6 years). Group 1 (10 mg/level) contained 47 patients (109 levels; 2.33 levels/patient) who underwent anterior spinal fusion (ASF): BMP on an absorbable collagen sponge (ACS) with a titanium mesh cage. Group 2 (20 mg/level) included 43 patients (156 levels; 3.63 levels/patient) with PSF: BMP on an ACS with local bone graft (LBG) and bulking agent [tricalcium phosphate/hydroxyapatite (TCP-HA)]. Group 3 (40 mg/level) contained 8 patients (43 levels; 5.38 levels/patient) with PSF: rhBMP-2 and TCP-HA with no autologous bone. Confounding negative factors were present in the study population: me...Continue Reading

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Citations

Mar 22, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Wei WangZiming Yu
Sep 6, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Thomas Lerner, Ulf Liljenqvist
Mar 22, 2012·Spine·Anthony L R MichaelPeter A Millner
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Jun 21, 2014·Current Reviews in Musculoskeletal Medicine·Brett WalkerKris Radcliff
May 21, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Wei YuanJian Dong
Jan 15, 2014·The Spine Journal : Official Journal of the North American Spine Society·Chadi A Tannoury, Howard S An
Apr 20, 2012·Advanced Drug Delivery Reviews·Kevin W-H LoCato T Laurencin
Nov 26, 2010·The Orthopedic Clinics of North America·Robert M Greenleaf, Daniel T Altman
May 10, 2013·Orthopaedic Surgery·Ralph J MobbsPrashanth J Rao
Mar 20, 2015·Drug Delivery and Translational Research·Kara L Spiller, Gordana Vunjak-Novakovic
Jul 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Keith H BridwellJeffrey C Wang
Dec 16, 2016·Clinical Spine Surgery : a Spine Publication·Varun PuvanesarajahHamid Hassanzadeh
Dec 18, 2013·Clinical Spine Surgery : a Spine Publication·Eric KlinebergRichard Hostin
Jan 23, 2019·Stem Cells Translational Medicine·Seth AndrewsSteven Stice
Feb 26, 2020·Spine·Amit JainUNKNOWN International Spine Study Group
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May 14, 2016·Clinical Spine Surgery : a Spine Publication·Richard HostinUNKNOWN International Spine Study Group, Denver, CO

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