Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling

The American Journal of Pathology
Udayan GuhaJohn A Kessler

Abstract

Hair follicle morphogenesis and cycling were examined in transgenic mice that overexpress the bone morphogenetic protein (BMP) inhibitor Noggin under the control of the neuron-specific enolase promoter. The Noggin transgene was misexpressed in the proximal portion of the hair follicle, primarily the matrix cells, apart from the usual expression in neurons. Transgene expression appeared only after induction of both the primary (tylotrich) and secondary (nontylotrich) pelage hair follicles had already occurred, thus allowing examination of the role of BMP signaling in follicles that had been induced normally in the presence of BMPs. The overexpression of Noggin in these animals resulted in a dramatic loss of hair postnatally. There was an apparently normal, but shortened period of postnatal hair follicle morphogenesis, followed by premature initiation of hair follicle cycling via entry into the first catagen transformation. This resulted in a complete loss of hair shafts from the nontylotrich hair follicles in these mice while the tylotrich hair follicles were normal. The onset of anagen of the first postnatal hair follicle cycle was also accelerated in the transgenic mice. Our results show that BMP signaling is specifically requ...Continue Reading

References

Feb 1, 1992·Trends in Genetics : TIG·M H Hardy
Dec 26, 1991·Annals of the New York Academy of Sciences·W M O'Guin, M Manabe
Jan 1, 1995·The Journal of Investigative Dermatology·M SeibergK S Stenn
Dec 1, 1996·The Journal of Investigative Dermatology·R B WidelitzC M Chuong
Dec 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H Takahashi, T Ikeda
Oct 1, 1996·Dermatologic Clinics·K S StennS M Prouty
Sep 26, 1997·The Journal of Comparative Neurology·V A BotchkarevR Paus
Aug 1, 1997·The Journal of Investigative Dermatology. Symposium Proceedings·R PausV A Botchkarev
Sep 15, 1998·The American Journal of Pathology·V A BotchkarevR Paus
Oct 13, 1998·Current Biology : CB·B St-JacquesA P McMahon
Jan 12, 1999·Developmental Biology·C ChiangA A Dlugosz
Jul 8, 1999·The American Journal of Pathology·A A PanteleyevR Paus
Aug 4, 1999·Nature Genetics·D J Headon, P A Overbeek
Aug 12, 1999·The New England Journal of Medicine·R Paus, G Cotsarelis
Nov 13, 1999·Nature Cell Biology·V A BotchkarevR Paus
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V A BotchkarevR Paus
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus
Jul 10, 2001·The Journal of Investigative Dermatology·S Müller-RöverR Paus
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V A BotchkarevB A Gilchrest
Nov 13, 2001·Developmental Cell·E FuchsR DasGupta
Feb 14, 2002·The Journal of Investigative Dermatology·Sarah E Millar
Feb 20, 2002·The Journal of Investigative Dermatology·Vladimir A BotchkarevBarbara A Gilchrest
May 23, 2002·Developmental Cell·Thomas AndlSarah E Millar
Jun 11, 2002·Biochemical and Biophysical Research Communications·Jianghong ZhangJian Q Feng
Jan 7, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Motonobu NakamuraRalf Paus
Jan 10, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Maranke I KosterDennis R Roop
May 21, 2003·Genes & Development·Laura Alonso, Elaine Fuchs
Aug 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·C NiemannF M Watt

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Citations

Mar 9, 2011·Pflügers Archiv : European journal of physiology·Balázs I TóthTamás Bíró
Jul 18, 2008·Human Molecular Genetics·Benjamin D YuCrystal Wong
May 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Theodora M MauroDavid Pearce
Sep 17, 2009·The American Journal of Dermatopathology·Noriyuki MisagoYutaka Narisawa
Apr 21, 2009·The International Journal of Developmental Biology·Maksim V PlikusCheng-Ming Chuong
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael A BonaguidiJohn A Kessler
Nov 5, 2011·Yi chuan = Hereditas·Rong DaiShou-Ren Liu
Dec 1, 2009·The International Journal of Biochemistry & Cell Biology·Marlon R Schneider, Ralf Paus
Nov 22, 2005·The Journal of Investigative Dermatology·Nicole Weger, Thomas Schlake
Jun 10, 2008·The Journal of Comparative Neurology·Alcmène ChalazonitisMichael D Gershon
Jan 4, 2012·Developmental Neurobiology·Alcmène Chalazonitis, John A Kessler
Dec 25, 2004·Differentiation; Research in Biological Diversity·Vladimir A Botchkarev, Andreij A Sharov
May 23, 2012·Genesis : the Journal of Genetics and Development·Rong HanJanice L Brissette
Nov 26, 2010·Developmental Biology·Alcmène ChalazonitisMichael D Gershon
Jun 28, 2005·Developmental Biology·Sophie VauclairFreddy Radtke
Jul 28, 2016·Cellular and Molecular Life Sciences : CMLS·Carmen Ehrmann, Marlon R Schneider
Feb 1, 2006·The British Journal of Dermatology·M A AdlyM R Hussein
Jan 13, 2006·The British Journal of Dermatology·K S LeslieS T Donel
Oct 25, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Randall B WidelitzCheng Ming Chuong
Feb 23, 2019·PloS One·Magdalena A T BrunnerMonika M Welle
Jul 2, 2019·Experimental Dermatology·Megan A PalmerIain S Haslam
May 30, 2019·Nature Communications·Alona FeldmanYaron Fuchs
Dec 2, 2020·Molecular and Cellular Endocrinology·Julieta María CerutiMaría Eugenia Balañá
Jul 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shefrin Salim, Kaladhar Kamalasanan
Nov 30, 2005·Development·Michael A BonaguidiJohn A Kessler
Nov 24, 2019·The Journal of Investigative Dermatology·Yuan HuCarlos Caulin
Dec 25, 2004·Differentiation; Research in Biological Diversity·Ralf Paus, Kerstin Foitzik

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