Bone Morphogenetic Proteins 2/4 Are Upregulated during the Early Development of Vascular Calcification in Chronic Kidney Disease

BioMed Research International
Xiao WeiSantao Ou

Abstract

Vascular calcification is a main cause of increased cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients. This study aimed to investigate the role of the bone morphogenetic protein (BMP) signaling pathway in the early development of vascular calcification in CKD. A CKD vascular calcification rat model was established by providing rats with a 1.8% high-phosphorus diet and an intragastric administration of 2.5% adenine suspension. The kidney and aortic pathologies were analyzed. Blood biochemical indicators, serum BMP-2 and BMP-4 levels, and aortic calcium content were determined. The expression levels of BMP-2, BMP-4, bone morphogenetic protein receptor-IA (BMPR-IA), and matrix Gla protein (MGP) in aorta were examined by quantitative real-time polymerase chain reaction and immunohistochemistry. Compared with the normal control (Nor) rats, the CKD rats exhibited a significantly decreased body weight and an increased kidney weight as well as abnormal renal function and calcium-phosphorus metabolism. Aortic von Kossa and Alizarin red staining showed massive granular deposition and formation of calcified nodules in aorta at 8 weeks. The aortic calcium content was significantly increased, which was positive...Continue Reading

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Citations

Apr 17, 2020·International Journal of Molecular Sciences·Sun Joo LeeJae-Han Jeon
Mar 9, 2020·Bulletin of Experimental Biology and Medicine·Yu F GorskayaV G Nesterenko
Sep 17, 2020·Journal of Developmental Biology·Daniel HalloranAnja Nohe
Oct 31, 2020·Journal of Cardiovascular and Thoracic Research·Behzad Zaker, Mohammadreza Ardalan

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Methods Mentioned

BETA
urine collection
light microscopy
ELISA
PCR

Software Mentioned

SPSS

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