Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease

Drug Discovery Today
James F Tobin, Anthony J Celeste

Abstract

Bone morphogenetic proteins (BMPs) and growth differentiation factors (GDFs) control the development and homeostasis of multiple tissue types in many organisms, from humans to invertebrates. These morphogens are expressed in a tissue-specific manner and they signal by binding to serine-threonine kinase receptors, resulting in coordinated changes in gene expression that regulate the differentiation and development of multiple tissue types. In addition, these proteins are regulated post-transcriptionally through binding to several soluble proteins. In this review we focus on a subset of BMPs and GDFs that have been implicated in the pathophysiology of type 2 diabetes and cardiovascular disease.

References

Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R BootcovS N Breit
Dec 31, 1997·Biochimica Et Biophysica Acta·R HromasL Lu
Jan 8, 1999·Stroke; a Journal of Cerebral Circulation·S Z LinY Wang
Mar 12, 1999·Mechanisms of Development·H NeuhausR S Thies
Dec 10, 1999·The Journal of Clinical Investigation·D W BensonJ D Kugler
Jun 13, 2000·The Journal of Biological Chemistry·A F MillerM S Olson
Jul 6, 2000·Nature Structural Biology·T KirschM K Dreyer
Jul 15, 2000·American Journal of Physiology. Renal Physiology·K A HruskaJ Morrissey
Sep 8, 2001·Stroke; a Journal of Cerebral Circulation·Y WangB J Hoffer
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Shi-Nong WangRaimund Hirschberg
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C R DhoreM J Daemen
Dec 18, 2001·Nutrition·U N Das
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Richard J LundKeith A Hruska
Jun 1, 2002·Science·Liliana Attisano, Jeffrey L Wrana
Oct 3, 2002·The European Respiratory Journal·M HumbertJ H Morse
Oct 3, 2002·The European Respiratory Journal·M Humbert, R C Trembath
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Atta BehfarMichel Pucéat
Dec 3, 2002·Nature·Sasha BogdanovichTejvir S Khurana
Feb 7, 2003·The New England Journal of Medicine·Lingling DuPatricia A Thistlethwaite
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Chen-Fu ChangYun Wang
May 20, 2003·Kidney International·Song WangKeith A Hruska
May 23, 2003·Journal of the American Society of Nephrology : JASN·Matthew R DaviesKeith A Hruska
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·A SweattR Wallin
Aug 14, 2003·American Journal of Physiology. Renal Physiology·Michael ZeisbergRaghu Kalluri
Aug 20, 2003·The Journal of Biological Chemistry·Su-Li ChengDwight A Towler

❮ Previous
Next ❯

Citations

Jun 2, 2010·Nature Reviews. Drug Discovery·Yu-Hua TsengC Ronald Kahn
Feb 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kristy L TownsendYu-Hua Tseng
Feb 18, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Aaron M Cypess, C Ronald Kahn
Aug 5, 2010·Physiological Genomics·Siddharth SukumaranRichard R Almon
Oct 23, 2010·Stroke; a Journal of Cerebral Circulation·Chuanhui DongRalph L Sacco
Dec 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ivan SosaDragica Bobinac
Jul 22, 2010·The Tohoku Journal of Experimental Medicine·Yang Ho KangSeok Man Son
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tim J SchulzYu-Hua Tseng
Nov 21, 2009·Cytokine & Growth Factor Reviews·Joachim NickelThomas D Mueller
Dec 19, 2007·Journal of Molecular and Cellular Cardiology·Thiago T MacielAlexandre H Campos
Oct 27, 2011·BMB Reports·Meejung Kim, Senyon Choe
Jan 21, 2014·Colloids and Surfaces. B, Biointerfaces·Michael J HeslingaOmolola Eniola-Adefeso
Apr 5, 2011·Diabetes Research and Clinical Practice·Jun ZengBing Chen
Nov 30, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Sabiniano RomanJuan A Marchal
Nov 5, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Simone BignozziMaurilio Marcacci
Sep 3, 2014·Endocrine·Supriya SainiShashi Bala Singh
Jan 21, 2017·BioMed Research International·Umesh D WankhadeKeshari M Thakali
Jan 26, 2020·Cells·Chandrakala Aluganti Narasimhulu, Dinender K Singla
Jun 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min YangLing Li
Feb 20, 2021·Frontiers in Pharmacology·Qin-Juan SunLan Zhong
Apr 8, 2020·ACS Pharmacology & Translational Science·Nimna PereraMitchel Tate
Aug 28, 2021·International Journal of Molecular Sciences·Luc RochetteCatherine Vergely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

Current Opinion in Nephrology and Hypertension
Tingting LiKeith A Hruska
Current Opinion in Genetics & Development
S J Lee, A C McPherron
Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Keiji MiyazawaK Miyazono
© 2022 Meta ULC. All rights reserved