Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes

Leukemia Research
Danka GrcevićAna Marusić

Abstract

We assessed the expression pattern and clinical relevance of BMPs and related molecules in multiple myeloma (MM). MM bone-marrow samples (n=32) had increased BMP4, BMP6, ACVR1 and ACVR2A, and decreased NOG expression compared with controls (n=15), with BMP6 having the highest sensitivity/specificity. Within MM bone-marrow, the source of BMPs was mainly CD138(+) plasma-cell population, and BMP6 and ACVR1 expression correlated with plasma-cell percentage. Using myeloma cell lines NCI H929 and Thiel we showed that BMPs induced ID1, ID2 and IL6, and suppressed CDKN1A and BAX gene expression, and BAX protein expression. Finally, BMPs partially protected myeloma cells from bortezomib- and TRAIL-induced apoptosis. We concluded that BMPs may be involved in MM pathophysiology and serve as myeloma cell biomarkers.

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Citations

Sep 27, 2013·PloS One·Valérie Camara-ClayetteVincent Ribrag
Jul 25, 2013·Critical Reviews in Oncogenesis·Kristina VanderWallAlan Lichtenstein
Sep 13, 2017·Infection and Immunity·Natasha SpottiswoodeHal Drakesmith
Mar 12, 2019·Genetics and Molecular Biology·Damian WodzińskiEwa Balcerczak
Apr 25, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marta LionettiAntonino Neri
Oct 23, 2020·Cytokine & Growth Factor Reviews·Erik Martinez-HackertToril Holien
Jun 27, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard J ViscontiJessica A Cottrell

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