PMID: 2506159Sep 1, 1989Paper

Bone necrosis and tumor induction following experimental intraoperative irradiation

International Journal of Radiation Oncology, Biology, Physics
B E PowersS J Withrow

Abstract

The bone of the lumbar vertebrae of 153 dogs was examined 2 and 5 years after intraoperative irradiation (IORT), fractionated external beam irradiation (EBRT), or the combination. Groups of dogs received 15 to 55 Gy IORT only, 10 to 47.5 Gy IORT combined with 50 Gy EBRT in 2 Gy fractions or 60 to 80 Gy EBRT in 30 fractions. Six MeV electrons were used for IORT, and EBRT was done using photons from a 6 MV linear accelerator. The paraaortic region was irradiated and the ventral part of the lumbar vertebrae was in the 90% isodose level. Two years after irradiation, the dose causing significant bone necrosis as determined by at least 50% empty lacunae in the vertebral cortex was 38.2 Gy IORT alone and 32.5 Gy IORT combined with EBRT. Five years after irradiation, the dose causing 50% empty lacunae was 28.5 Gy IORT only and 14.4 Gy IORT combined with EBRT. The ED50 for lesions of the ventral vertebral artery was 21.7 Gy IORT only and 20.1 Gy IORT combined with 50 Gy EBRT 2 years after irradiation and 27.0 Gy IORT only and 20.0 Gy IORT combined with 50 Gy EBRT 5 years after irradiation. All lesions after EBRT only were mild. Eight dogs developed osteosarcomas 4 to 5 years after irradiation, one at 47.5 Gy IORT only and the remainder ...Continue Reading

References

Oct 1, 1988·International Journal of Radiation Oncology, Biology, Physics·H J HoekstraT J Kinsella
Dec 1, 1988·International Journal of Radiation Oncology, Biology, Physics·E L GilletteS J Withrow
Jan 1, 1986·Leukemia Research·W Gössner
May 1, 1987·International Journal of Radiation Oncology, Biology, Physics·P J HoopesS J Withrow
Jun 1, 1986·Neurosurgery·N SundaresanW G Cahan
Dec 1, 1986·American Journal of Clinical Oncology·W F SindelarT J Kinsella
Oct 1, 1984·International Journal of Radiation Oncology, Biology, Physics·J E TepperT Rich
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·M Abe, M Takahashi

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Citations

Oct 12, 2000·Journal of Surgical Oncology·Y Z InoueR A McLeod
Oct 1, 1995·Journal of Surgical Oncology·H J WallaceH C Hoover
Jun 17, 2005·European Radiology·Yoshitaka SatoHarumi Itoh
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·P A JohnstoneW F Sindelar
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·G E Hanks, R M Lanciano
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·I AzinovicR Martínez-Monge
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·N OyaM Hiraoka
Jun 18, 2014·ILAR Journal·Joelle M FengerWilliam C Kisseberth
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·S TakahashiM Takahashi
Mar 3, 2004·Surgical Oncology Clinics of North America·William F Sindelar, Timothy J Kinsella
Jun 1, 2003·Veterinary and Comparative Oncology·R J MellanbyJ M Dobson
Jan 1, 1995·The Veterinary Clinics of North America. Small Animal Practice·M C McEntee
Jan 1, 1997·The Veterinary Clinics of North America. Small Animal Practice·R L Burk
Sep 18, 2004·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Margaret C McEnteeDonald E Thrall
Sep 1, 1994·Current Problems in Cancer·P A JohnstoneT J Kinsella
Dec 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M CromheeckeH J Hoekstra
Dec 1, 2004·Journal of the American Veterinary Medical Association·James P FareseFrancis J Bova
Apr 19, 2008·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Kenji HosoyaChieko Azuma
Oct 27, 2001·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·P J DickinsonR A LeCouteur
Oct 22, 2005·Orthopedics·Tomitaka NakayamaTakashi Nakamura
Dec 1, 1994·International Journal of Radiation Oncology, Biology, Physics·S TakahashiT Yamamuro

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