Bone Pain and Muscle Weakness in Cancer Patients

Current Osteoporosis Reports
Daniel P MilgromTeresa A Zimmers

Abstract

In this article, we will discuss the current understanding of bone pain and muscle weakness in cancer patients. We will describe the underlying physiology and mechanisms of cancer-induced bone pain (CIBP) and cancer-induced muscle wasting (CIMW), as well as current methods of diagnosis and treatment. We will discuss future therapies and research directions to help patients with these problems. There are several pharmacologic therapies that are currently in preclinical and clinical testing that appear to be promising adjuncts to current CIBP and CIMW therapies. Such therapies include resiniferitoxin, which is a targeted inhibitor of noceciptive nerve fibers, and selective androgen receptor modulators, which show promise in increasing lean mass. CIBP and CIMW are significant causes of morbidity in affected patients. Current management is mostly palliative; however, targeted therapies are poised to revolutionize how these problems are treated.

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Citations

Sep 19, 2017·Current Opinion in Supportive and Palliative Care·Fabio PennaPaola Costelli
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May 8, 2021·Current Pain and Headache Reports·David HaoVwaire Orhurhu

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