PMID: 8968024Dec 1, 1996Paper

Bone particles disturb new bone formation on the interface of the titanium implant after reaming of the marrow cavity

Bone
M IshizakaH E Takahashi

Abstract

Histomorphometric studies were conducted in rats to determine whether bone particles would disturb new bone formation on the interface of titanium implants inserted after reaming of the marrow cavity. In eighty 10-week-old female Wistar rats, smooth-surfaced titanium alloy implants were inserted bilaterally into the marrow cavity after reaming in the distal femur. There were three experimental groups: in the irrigated femora, sterile saline was flushed through the medullary canal; in the particle femora, autologous bone particles were inserted into the intramedullary cavity; and in the reamed femora, the implant was inserted without procedures after reaming. The rats were sacrificed at one, two, four or eight weeks postoperatively, and Villanueva bone staining was applied for histomorphometric studies. The bone volume of new bone on the interface of the implant in the irrigated femora was greater than that in the particle or the reamed femora throughout the study period. The results suggest that clearance of bone particles by irrigation after reaming of the marrow cavity significantly facilitates new bone formation on the interface of implants by one week. The findings also suggest the potential clinical application of total ca...Continue Reading

References

Jun 1, 1975·Journal of Dental Research·D C Smith
Nov 12, 1965·Science·M R Urist

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Citations

Dec 18, 2008·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yutaka OhkawaNaoto Endo
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Xiaojun YuCato T Laurencin
Apr 27, 2000·The Pediatric Infectious Disease Journal·H C MaltezouK V Rolston
Sep 21, 2012·The Journal of Bone and Joint Surgery. American Volume·Amarjit S VirdiDale R Sumner
Jun 20, 2013·Journal of Tropical Pediatrics·Amit Kumar GuptaArushi Verma
Jun 29, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Xudong LiJing Hu
Jul 1, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·A De RanieriD R Sumner
Jan 6, 2004·Journal of Biomedical Materials Research. Part a·Moreica B PabbruweC Rolfe Howlett
Dec 9, 2014·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Guy SovakAnna Weiss

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