Bone Protective Effects of Danggui Buxue Tang Alone and in Combination With Tamoxifen or Raloxifene in vivo and in vitro

Frontiers in Pharmacology
Li-Ping ZhouMan-Sau Wong

Abstract

Danggui Buxue Tang (DBT), a traditional Chinese Medicine decoction containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), is commonly prescribed for women in China as a remedy for menopausal symptoms. Previous study indicated that DBT stimulated cell growth and differentiation of human osteosarcoma MG-63 cells and exhibited estrogenic properties via estrogen receptors (ERs). The present study aimed to study the bone protective effects of DBT and its potential interactions with selective estrogen receptor modulators (SERMs, tamoxifen and raloxifene) in both in vivo and in vitro models as they act via similar ERs. Six-month-old Sprague-Dawley rats were randomly assigned to the following treatments for 12 weeks: (1) sham-operated control group with vehicle (sham), (2) ovariectomized group with vehicle (OVX), (3) OVX with 17β-estradiol (E2, 2.0 mg/kg day), (4) OVX with tamoxifen (Tamo, 1.0 mg/kg day), (5) OVX with raloxifene (Ralo, 3.0 mg/kg day), (6) OVX with DBT (DBT, 3.0 g/kg day), (7) OVX with DBT+Tamoxifen (DBT+Tamo), and (8) OVX with DBT+Raloxifene (DBT+Ralo). Effects of DBT and potential interactions between DBT and SERMs were also evaluated in MG-63 cells. DBT, tamoxifen, raloxifene, and their combinations sign...Continue Reading

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Citations

Jul 6, 2020·BMC Complementary Medicine and Therapies·Hangsheng BaoXin Li
Sep 24, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yongming ShuaiFanhui Zeng
Dec 20, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Liping ZhouMan-Sau Wong
Jul 10, 2021·Oxidative Medicine and Cellular Longevity·Lang YangJunxiang Peng

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Methods Mentioned

BETA
hormone replacement therapy
Assay
ELISA
PCR

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