PMID: 6979977May 1, 1982Paper

Bone rarefaction and crush fractures in juvenile chronic arthritis

Archives of Disease in Childhood
U ElsasserB M Ansell

Abstract

Seventy children with juvenile chronic arthritis have had measurements of cortical and trabecular bone density in one or both radii. In 7 children with unilateral disease of one wrist, there was a substantial reduction in growth on the affected side. Trabecular bone density in the distal radius was reduced in the main group of 63 patients compared with controls, and this deficit was appreciably worse if the wrist was clinically affected by disease or if the child was being treated with steroids. Cortical bone density in the midshaft was less affected. Crush fractures of the spine were associated with more prolonged periods of bed rest, steroid therapy, radial trabecular bone density more than 2 standard deviations below normal, and subnormal 25-hydroxycholecalciferol concentrations in the serum. Since steroid therapy is often mandatory the main therapeutic implications are that the more severely affected child often needs vitamin D supplementation in "physiological" dosage, and that early mobilisation and reduction of steroid dosage should be constant aims.

References

Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J G Haddad, K J Chyu
Sep 1, 1980·British Medical Bulletin·U Elsasser, J Reeve
Nov 1, 1954·Journal of Clinical Pathology·P R KIND, E J KING
Dec 1, 1956·Annals of the Rheumatic Diseases·B M ANSELL, E G BYWATERS
Jun 1, 1960·Annals of the Rheumatic Diseases·B W BADLEY, B M ANSELL

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Citations

May 1, 1996·Arthritis and Rheumatism·P H PepmuellerL S Hillman
Apr 1, 2008·Indian Journal of Pediatrics·Ozgur OkumusMine Okumus
Nov 12, 2005·Current Opinion in Pediatrics·Kelly A Rouster-Stevens, Marisa S Klein-Gitelman
Mar 16, 2011·Journal of Osteoporosis·Kristyna Brabnikova Maresova
Jun 20, 1998·Journal of Endocrinological Investigation·F FalciniF Bagnoli
Jan 20, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N DalzellJ Reeve
Nov 1, 1989·Arthritis and Rheumatism·G SinghO P Ghai
Aug 1, 1997·Rheumatic Diseases Clinics of North America·J T Cassidy, L S Hillman
May 10, 2003·Rheumatology International·Reyhan CelikerFitnat Dinçer
Apr 17, 2007·European Journal of Pediatrics·Johannes RothMichael Borte
Mar 1, 2007·Arthritis and Rheumatism·Kelly A Rouster-StevensLauren M Pachman
May 18, 2018·Pediatric Rheumatology Online Journal·Sarah L FinchHassan Vatanparast
Nov 1, 1994·Archives of Physical Medicine and Rehabilitation·K K LyngbergB Danneskiold-Samsøe

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