Bone regeneration and repair

Current Stem Cell Research & Therapy
Nicholas J PanettaMichael T Longaker

Abstract

In the face of mounting clinical demand, and armed with reconstructive techniques that are technically challenging and frequently result in suboptimal patient outcomes, increasing focus is being placed on tissue engineering and regenerative medicine as a potential source of novel skeletal reconstructive approaches. Specifically, evidence is accumulating that highlights the promise of osteoprogenitor cell-based reconstructive strategies to meet the needs of an expanding patient population. Historically, the study of cell and molecular biology guiding physiologic and pathologic skeletal development, as well as endogenous bone regeneration following injury, has provided a wealth of information that lends insight toward potential parallel processes that may regulate the osteogenic differentiation of progenitor cells. Multiple progenitor cell populations are now known to possess a capacity to undergo robust osteogenic differentiation in the presence of appropriate environmental cues (hESC, BMSC, ASC, etc.) Recent investigations have put forth multiple advantages of ASC relative to BMSC. Of note, ASC exist in relative abundance, lack the need for in vitro expansion prior to utilization, and can be harvested with relative ease and red...Continue Reading

Citations

Dec 15, 2010·Journal of Periodontology·Zhao LinWilliam V Giannobile
Aug 13, 2013·BioMed Research International·Marco GovoniEmanuele Giordano
Mar 2, 2012·Canadian Journal of Physiology and Pharmacology·Angelika Jamnig, Günter Lepperdinger
Aug 16, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·ZuFu LuHala Zreiqat
Feb 14, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dénes B HorváthyZsombor Lacza
Jun 19, 2013·International Journal of Experimental Pathology·Jedd B SereyskyNelly Andarawis-Puri
Jan 31, 2014·Journal of Tissue Engineering and Regenerative Medicine·Rainer Detsch, Aldo R Boccaccini
May 7, 2014·Journal of Biomedical Materials Research. Part a·D ClarkJ Liu
Apr 6, 2011·Biochemical and Biophysical Research Communications·Insun SongGun-Il Im
Jun 14, 2018·Tissue Engineering. Part B, Reviews·Xiaojing WangBaodong Zhao
Mar 9, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xiaonan XinDavid W Rowe
Oct 17, 2019·Journal of Biomedical Materials Research. Part a·Muhammad QasimNae Yoon Lee
Aug 16, 2017·Experimental and Therapeutic Medicine·Zhaolong XueJianhua Ge
Dec 11, 2020·Clinical and Experimental Pharmacology & Physiology·Young-Ju LimWon-Gu Jang
Mar 5, 2021·Science Translational Medicine·Takamitsu MaruyamaWei Hsu
Jun 30, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Yi HeDongsheng Yu
Sep 2, 2021·Journal of Applied Biomaterials & Functional Materials·Rui ZhaoQizhi Wang

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