Bone regeneration in osseous defects-application of particulated human and bovine materials

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Christian TudorE Felszeghy

Abstract

Different bone substitute materials are used to manage the challenge of local bone loss subsequent to craniofacial reconstructive surgery. In this animal study we examined the de novo bone formation in bone defects after insertion of Puros Allograft of human origin or Navigraft of bovine origin, and compared the regenerative potential of each material to that of autogenous bone. Using the adult domestic pig as the animal model, we created identical bone defects in the frontal skull and filled them with the different test materials using random assignment. A defined number of defects remained unfilled to serve as control. We performed microradiographic, histologic, and polychromatic fluorescence labeling evaluations of the bone specimens at 1, 8, and 12 weeks after the procedure. Both of the materials that we tested allowed for complete bony consolidation of the defects by the end of the test period. After 12 weeks, the microradiographically measured mineralization rate was 5% to 10% lower than the mineralization rate of autogenous bone grafts. Both Puros Allograft and Navigraft met the clinical requirements for bone substitutes, promoting predictable regeneration of the bony defects.

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Citations

Dec 16, 2011·Journal of Pharmaceutical and Biomedical Analysis·Joanna KolmasWaclaw Kolodziejski
Jul 5, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Philipp StockmannKarl Andreas Schlegel
Mar 27, 2015·Journal of Oral Science·Ulaş GörmezKenan Dağlioğlu
Aug 19, 2014·Journal of Clinical Periodontology·Tobias MoestKarl Andreas Schlegel
Dec 11, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Ibrahim DamlarYakup Üstün
Jan 31, 2018·The Journal of Craniofacial Surgery·Babak Hatami KiaReinhard Gruber
Jun 4, 2013·Journal of Applied Biomaterials & Functional Materials·Michela BosettiMario Cannas

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