PMID: 9530668Apr 8, 1998Paper

Bone regeneration stimulated by bone substitute materials

Der Orthopäde
H StützleL Schweiberer

Abstract

Prompted by severe problems in autogeneic and allogeneic bone transplantation, intensive efforts were made to find sufficient substitutes. A main demand on these materials, especially in healing of osseous defects, is to achieve results comparable to those of auto- or allografts. These must be related to their biomechanical and particularly to their biological properties, i.e. the ability to form new bone, osseous integration and physiological remodeling. Within different trials in the tibiae of sheep we investigated bone substitutes like hydroxyapatite ceramics (HA) or partially demineralized bone matrix (pDBM) and compared them to the gold standards of autogeneic and allogeneic bone transplantation. Therefore we used two different models: the drill hole model with small size defects of 6 mm in diameter and the shaft defect model as a true-to-life defect with a 5 cm large diaphyseal defect. Evaluation was done by X-rays, histology, microradiography, fluorescent microscopy and morphometry of the small size defects. HA showed only small effects on new bone formation and works merely as an osteoconductor. However, excellent new bone formation was regularly achieved by pDBM in the small defects, whereas it was limited in the large...Continue Reading

Citations

Aug 11, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Christian H FlammeChristof Hurschler
Jul 21, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Holger E KoeppAnita A Ignatius
Jun 17, 2015·Oral and Maxillofacial Surgery Clinics of North America·Michael S Block
Jun 28, 2006·Mund-, Kiefer- und Gesichtschirurgie : MKG·Hans-Henning Horch, Christoph Pautke
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Apr 9, 2009·Zeitschrift für Psychosomatische Medizin und Psychotherapie·Cord BeneckeStephan Doering
Aug 14, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Henriette BretschneiderChristine Hofbauer
Jul 10, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Karl Andreas SchlegelEndre Felszeghy

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