Bone remodeling regulation under unloading conditions: numerical investigations

Computers in Biology and Medicine
Sébastien BaiottoM Zidi

Abstract

The present paper addresses the following question: can a simple regulatory bone remodeling model predict effects of unloading conditions on the trabecular bone morphology? In an attempt to answer this question, rat tail-suspension was chosen as a model that mimics the microgravity environment. Over 23 days, histomorphometric analysis was carried out on cross-sections of tibias of the suspended animals. The slices were digitalized and images discretized to obtain osteocyte distribution and apparent bone density. Based on these experimental data, finite element simulations were conducted to evaluate the bone loss and the change in trabecular architecture similar to those observed after a spaceflight. The numerical model is driven by a remodeling law that takes into account the nonuniform osteocyte distribution that may itself provide mechanoreception. We used the bone density rate of change from the remodeling theory and a time stepping algorithm witch are implemented in a finite element software. This approach takes into account the unloading effects on bone remodeling process and permits to confront experimental and numerical data. We showed that there is a good agreement between these data, particularly at the beginning of th...Continue Reading

References

May 1, 1992·Journal of Biomechanics·S J SimskeM W Luttges
May 1, 1991·Journal of Biomechanical Engineering·S C CowinM L Moss
Nov 1, 1993·Journal of Biomechanical Engineering·S C Cowin
May 26, 1998·Bone·E H Burger, J Klein-Nulend
Jul 10, 1999·Journal of Biomechanics·M Zidi, S Ramtani
Feb 24, 2001·Journal of Biomechanical Engineering·M Zidi, S Ramtani
Jun 8, 2002·Journal of Biomechanics·Zhu XinghuaGao Bingzhao
Jul 10, 2004·Biomechanics and Modeling in Mechanobiology·S Baiotto, M Zidi
Feb 16, 2005·Annals of Biomedical Engineering·Ian D McCarthy
Dec 2, 2006·Dental Materials : Official Publication of the Academy of Dental Materials·Jianying LiNick Silikas

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Citations

Apr 16, 2013·Biomechanics and Modeling in Mechanobiology·Hong WangKeh-Chih Hwang
Jun 19, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Amir Abbas Zadpoor
Feb 25, 2015·Bone·Pascal R Buenzli, Natalie A Sims

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