Bone-resorbing activity of thyroid hormones is related to prostaglandin production in cultured neonatal mouse calvaria

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
K KlaushoferM Peterlik

Abstract

The bone-resorbing activity of thyroid hormones was evaluated in neonatal mouse calvaria maintained in organ culture for 96 h. Thyroxine (T4) between 10(-8) and 10(-5) mol/liter and triiodothyronine (T3) between 10(-8) and 10(-7) mol/liter caused a dose-dependent release of calcium from cultured bone. The thyroid hormone effect was delayed in onset for at least 24 h, and after 96 h of culture amounted to 50-90% of the bone-resorbing activity of 10(-8) mol/liter parathyroid hormone (PTH). The bone-resorbing action of T4 as well as of T3 was completely blocked by 100 U/ml interferon-gamma (IF-gamma) or 20 mU/ml salmon calcitonin (CT). "Escape" from CT inhibition, which is a well-known phenomenon in the action of PTH, was not observed with thyroid hormone-mediated bone resorption. Thyroid hormone treatment of cultured calvaria resulted in a gradual increase between 48 and 96 h of medium concentrations of prostaglandin (PG) E2 and particularly of 6-keto-PGF1 alpha, the inactive metabolite of prostacyclin (PGI2). The release of PGF2 alpha in general was not significantly affected. Although the effect of thyroid hormones on PG release from cultured calvaria was completely abolished by 5 x 10(-7) mol/liter indomethacin, in some experi...Continue Reading

References

Sep 1, 1976·The Journal of Clinical Investigation·G R MundyL G Raisz
Dec 14, 1978·Biochemical and Biophysical Research Communications·A H Tashjian, L Levine
Jul 1, 1979·Acta Endocrinologica·J Linde, T Friis
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E R FroeschK D Gibson
Aug 1, 1975·Prostaglandins·J W DietrichL G Raisz
Jan 1, 1986·Metabolism: Clinical and Experimental·R RizzoliU Bürgi
Feb 1, 1987·The Journal of Clinical Investigation·N S KriegerP H Stern
Feb 27, 1987·Biochemical and Biophysical Research Communications·O HoffmannM Peterlik
Aug 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N S KriegerP H Stern
Oct 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U H Lerner
Jun 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R Bouillon, P De Moor
Jun 1, 1970·Endocrinology·D C Klein, L G Raisz
Mar 1, 1969·The Journal of Clinical Endocrinology and Metabolism·H P KatzM M Grumbach
Sep 1, 1983·Acta Endocrinologica·J W BijlsmaP J der Kinderen
Dec 5, 1980·Biochimica Et Biophysica Acta·E F VoelkelL Levine
Mar 1, 1983·Bioscience Reports·G T Gustafson, U Lerner
Oct 1, 1980·The Journal of Clinical Endocrinology and Metabolism·R BouillonP De Moor
Apr 1, 1981·Acta Endocrinologica·J MarekZ Límanová

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Citations

Sep 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N F Ivankina Mischenko TYa
Jul 1, 1997·Experimental Gerontology·M Peterlik
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·K W Wenzel
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B K HuangP H Stern
Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L G Raisz
Nov 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U H Lerner
Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P LakatosP H Stern
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G Tarjan, P H Stern
Feb 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H KawaguchiL G Raisz
Feb 11, 2016·Endocrine Reviews·J H Duncan Bassett, Graham R Williams
Apr 17, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Stephanie KeerLuz Patricia Hernandez
Jan 8, 2020·Thyroid : Official Journal of the American Thyroid Association·Franziska LademannMartina Rauner
May 27, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Franziska LademannMartina Rauner
Jun 9, 2001·Experimental Biology and Medicine·B A WatkinsM F Seifert
Jun 1, 2013·Bone Research·Ha-Young Kim, Subburaman Mohan
Oct 1, 1991·Journal of Endocrinological Investigation·D S Ross, R Graichen
May 10, 2007·Molecular Endocrinology·J H Duncan BassettGraham R Williams
Jul 29, 2004·Journal of Cellular Physiology·Masanori KanataniKazuo Chihara
Jan 21, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Franziska LademannMartina Rauner
Feb 5, 2002·Molecular Genetics and Metabolism·Clare B HarveyGraham R Williams
May 1, 1992·Trends in Endocrinology and Metabolism : TEM·J A Franklyn, M C Sheppard
Aug 17, 2010·Biochemical and Biophysical Research Communications·F VargaK Klaushofer

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