PMID: 11605744Oct 19, 2001Paper

Bone-resorbing cytokines from peripheral blood mononuclear cells after hormone replacement therapy: a longitudinal study

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
O Bernard-PoenaruM E Cohen-Solal

Abstract

Conflicting results have been reported in several cross-sectional studies measuring cytokine production from adherent monocytes in pre- and postmenopausal women. Furthermore, the target cells for the action of estrogen are still debated. We therefore assessed in a longitudinal manner the cytokine production from different fractions of peripheral blood mononuclear cells (PBMC) cultured for 48 h. PBMC were obtained from 30 postmenopausal women before and after 6 months of hormone replacement therapy (HRT). Women were randomly allocated to two groups: an adherent PBMC group (n = 20) and a total PBMC group (n = 9). After 6 months of treatment, urinary pyridinoline levels were markedly decreased in both groups (353+/-24 vs 114+/-13 microg/mmol creatinine and 325+/-35 vs 164+/-31 microg/mmol creatinine respectively, p<0.01). Culture supernatants were assayed for interleukin 1beta (IL-1beta), interleukin 6 (IL-6), soluble IL-6 receptor (IL-6rs) and tumor necrosis factor alpha (TNF-alpha). In the adherent PBMC group, HRT induced a nonsignificant trend toward decreased levels of IL-1beta (35+/-10 vs 13+/-5 pg/ml), TNF-alpha (333+/-58 vs 222+/-30 pg/ml) and IL-6 (115+/-70 vs 17+/-10 pg/ml). In contrast, in the total PBMC group, HRT induc...Continue Reading

Citations

Jan 1, 2012·BoneKEy Reports·Lucia D'Amico, Ilaria Roato
May 3, 2008·Endocrine Reviews·Joseph LorenzoYongwon Choi
Mar 11, 2005·European Journal of Endocrinology·Thor Ueland
Mar 1, 2016·Frontiers in Immunology·Roberto Pacifici
Jan 23, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Asli SomunkiranOguz Yucel
Jan 8, 2015·Journal of Exercise Nutrition & Biochemistry·Chang Sun KimHyo Jin Kim
Jan 25, 2005·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Takashi OdaYasuo Kokai
Jul 13, 2006·Annals of the New York Academy of Sciences·Alberta Zallone
Mar 19, 2014·Acta Physiologica Hungarica·A HassounaMohamed Haidara
Apr 26, 2016·The Journal of Clinical Investigation·Jau-Yi LiRoberto Pacifici
Aug 30, 2017·Cold Spring Harbor Perspectives in Medicine·Roberto Pacifici
Oct 12, 2017·Calcified Tissue International·Emory Hsu, Roberto Pacifici
Dec 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrizia D'AmelioGiancarlo Isaia
Apr 11, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jane A CauleyUNKNOWN Health ABC Study
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Feb 15, 2002·Endocrine Reviews·Johannes PfeilschifterHelmut Schatz
Jul 31, 2020·Endocrinology·Franck Mauvais-JarvisEllis R Levin
Apr 24, 2019·Journal of Exercise Nutrition & Biochemistry·Ji-Yeon KimChang-Sun Kim

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