PMID: 3761006Aug 1, 1986Paper

Bone resorption, renal function and mineral status in cows treated with 1,25-dihydroxycholecalciferol and its 24-fluoro analogues

The Journal of Nutrition
J P GoffM R Uskokovic

Abstract

The relative potencies of 1,25-dihydroxycholecalciferol, 24-F-1,25-dihydroxycholecalciferol, and 24,24-F2-1,25-dihydroxycholecalciferol at three doses (25, 100 or 400 micrograms) were assessed in nonlactating Jersey cows. The 24,24-F2-1,25-dihydroxycholecalciferol induced a significantly greater hypercalcemia and hyperphosphatemia than did 1,25-dihydroxycholecalciferol. The 24-F-1,25-dihydroxycholecalciferol was intermediate in its hypercalcemic and hyperphosphatemic potency. Urinary hydroxyproline excretion rate and plasma hydroxyproline concentration were not significantly increased by treatment with any of the compounds. This indicates that these compounds did not stimulate bone resorption in nonlactating, nongravid cows. Renal function was significantly impaired in cows that received a 400-micrograms dose of any compound. There was a severe reduction in glomerular filtration rate (up to 42%) and urine specific gravity. Renal function was most severely affected in cows treated with 24,24-F2-dihydroxycholecalciferol and was evident even at the 100-micrograms dosage level.

Citations

Sep 30, 2010·The Journal of Veterinary Medical Science·Danil KimShuichi Ohashi
Nov 22, 2011·Nutrition Research Reviews·Javier Martín-Tereso, Martin W A Verstegen
May 1, 1988·Journal of Dairy Science·J P GoffE T Littledike
Dec 1, 1995·Journal of Dairy Science·F G HustmyerT A Reinhardt
May 1, 1997·Journal of Dairy Science·K A StephensonL B Lowe
Jul 25, 2015·Animal Science Journal = Nihon Chikusan Gakkaihō·Junichiro IshiiHisaya Goto
Jul 1, 1994·Journal of Dairy Science·R L HorstT A Reinhardt
May 16, 2017·Journal of Dairy Science·A Vieira-NetoJ E P Santos
Sep 14, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·B SchröderG Breves
Jul 11, 1998·Preventive Veterinary Medicine·M Bigras-Poulin, A Tremblay

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