Bone Status Among Patients With Nonsurgical Hypoparathyroidism, Autosomal Dominant Hypocalcaemia, and Pseudohypoparathyroidism: A Cohort Study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Line UnderbjergLars Rejnmark

Abstract

Nonsurgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP) are both rare diseases, characterized by hypocalcemia. In Ns-HypoPT, PTH levels are low, whereas patients with PHP often have very high levels due to receptor-insensitivity to PTH (PTH-resistance). Accordingly, we hypothesized that indices of bone turnover and bone mineralization/architecture are similar in Ns-HypoPT and PHP despite marked differences in PTH levels. We studied 62 patients with Ns-HypoPT and 31 with PHP as well as a group of age- and sex-matched healthy controls. We found a significantly higher areal BMD (aBMD) by DXA among patients with Ns-HypoPT, both compared with PHP and the background population. Compared with Ns-HypoPT, PHP patients had significantly lower total and trabecular volumetric BMD (vBMD) assessed by quantitative computed tomography (QCT) scans at the spine and hip. High-resolution peripheral quantitative computed tomography (HRpQCT) scans showed a lower trabecular area and vBMD as well as a lower trabecular number at the tibia in PHP compared to Ns-HypoPT and matched controls. In PHP, PTH levels correlated with levels of markers of bone formation (osteocalcin, bone-specific alkaline phosphatase, P1NP), and bone resorpt...Continue Reading

References

Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·N A BreslauC Y Pak
Jun 1, 1982·The Journal of Clinical Investigation·E SeemanB L Riggs
Jan 1, 1980·Acta Endocrinologica·G WägarA Sivula
Feb 1, 1993·Journal of Medical Genetics·S J Davies, H E Hughes
Feb 18, 1999·The Journal of Clinical Endocrinology and Metabolism·Y DuanE Seeman
Apr 1, 1999·The New England Journal of Medicine·Z FarfelT Iiri
Nov 9, 2000·The Journal of Clinical Investigation·J LiuL S Weinstein
Mar 15, 2001·European Journal of Endocrinology·M KanataniK Chihara
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·V Vlaeminck-GuillemJ L Wémeau
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Fredriech K W ChanChi-Chung Shek
Feb 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert LindsayDavid W Dempster
Jan 18, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert LindsayAnthony B Hodsman
Jul 20, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Fernando RivadeneiraHuibert Ap Pols
Oct 2, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Etienne CavalierPierre Delanaye
Jul 25, 2008·The New England Journal of Medicine·Dolores Shoback
Aug 8, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mishaela R RubinJohn P Bilezikian
Dec 25, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B C C KhooR L Prince
Sep 17, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Z LaCroixZ Chen
Oct 24, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Carsten S HøjskovHolger J Møller
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stinus HansenKim Brixen
Jul 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Dominique N LongEmily L Germain-Lee
Nov 11, 2010·European Journal of Endocrinology·Anne Marie SbrocchiLeanne Marie Ward
Jul 8, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mishaela R RubinJohn P Bilezikian
Jul 21, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tanja SikjaerUNKNOWN Hypoparathyroid Study Group
Aug 4, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John P BilezikianJames Sanders
Apr 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stinus HansenClaus H Gravholt
Apr 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rachel I GafniMichael T Collins
Jan 21, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara C SilvaJohn P Bilezikian
Jun 5, 2014·Calcified Tissue International·Niels Frederik Breum JakobsenLars Rejnmark
Mar 11, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Line UnderbjergLars Rejnmark
Aug 4, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Natalie E CusanoJohn P Bilezikian
Nov 1, 2016·Journal of Bone and Mineral Metabolism·Anne Kristine AmstrupLars Rejnmark
Sep 22, 2015·Clinical Endocrinology·Line UnderbjergLars Rejnmark
Sep 1, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B C SilvaJ P Bilezikian
Nov 3, 2016·Frontiers in Physiology·Kelly L RoszkoMichael Mannstadt

❮ Previous
Next ❯

Citations

Jun 14, 2018·The Journal of Clinical Endocrinology and Metabolism·Karen K Winer
May 3, 2019·The New England Journal of Medicine·Rachel I Gafni, Michael T Collins
Jan 8, 2021·Journal of the Endocrine Society·María Belén ZanchettaAna María Galich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Tanja SikjaerLeif Mosekilde
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Jakob Høgild LangdahlMorten Frost
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Natalie E CusanoJohn P Bilezikian
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
E A MarquesT B Harris
Scandinavian Journal of Gastroenterology
Kristin Matre AasarødReidar Fossmark
© 2022 Meta ULC. All rights reserved