Abstract
Although the loss of bone mineral density (BMD) after total hip arthroplasty (THA) is a known problem, it remains unresolved. This study prospectively examined the effect of zoledronic acid (ZA) on bone turnover and BMD after cementless THA. Between January 2010 and August 2011, 60 patients who underwent cementless THA were randomly assigned to receive either ZA infusion or placebo (0.9% normal saline only) postoperatively. ZA was administered at 2 day and 1 year postoperatively. Periprosthetic BMD in seven Gruen zones was assessed preoperatively and at given time points for 2 years. Serum markers of bone turnover, functional scales, and adverse events were recorded. Each group contained 27 patients for the final analysis. The loss of BMD across all Gruen zones (significantly in zones 1 and 7) up to 2 years postoperatively was noted in the placebo group. BMD was significantly higher in the ZA group than in the placebo group in Gruen zones 1, 2, 6, and 7 at 1 year and in Gruen zones 1, 6, and 7 at 2 years (p < 0.05). Compared with baseline measures of BMD, the ZA group had increased BMD in zones 1, 2, 4, 5, 6, and 7 at 1 year and in zones 1, 4, 6, and 7 at 2 years (p < 0.05). Serum bone-specific alkaline phosphatase and N-telope...Continue Reading
References
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P K VenesmaaE M Alhava
Mar 17, 2004·Acta Orthopaedica Scandinavica·Henrik Bodén, Per Adolphson
Aug 19, 2004·Cancer·Gaoping ChenShafaat A Rabbani
Feb 3, 2005·The Journal of Bone and Joint Surgery. American Volume·Mohit BhandariThomas A Einhorn
Mar 30, 2005·The Journal of Bone and Joint Surgery. British Volume·L SavarinoA Giunti
Nov 25, 2006·Hematology·Bhoomi Mehrotra, Salvatore Ruggiero
Feb 22, 2007·Clinical Orthopaedics and Related Research·A H GlassmanM Tanzer
May 4, 2007·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial
Aug 5, 2008·The Journal of Arthroplasty·Dave Weichih ChenMel S Lee
Aug 30, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mohammad ArabmotlaghMichael Rauschmann
Nov 6, 2008·Clinical Interventions in Aging·Irene LambrinoudakiK Papadias
Feb 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Gerald FriedlReinhard Windhager
Mar 5, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Erik Fink EriksenPeter Mesenbrink
Apr 2, 2009·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Harumoto YamadaEiichi Fukaya
Nov 18, 2009·Acta Orthopaedica·Jessica J AlmHannu T Aro
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eric S OrwollRobert S Weinstein
Sep 11, 2010·Seminars in Arthritis and Rheumatism·Jeroen P JansenMelvin Olson
Nov 3, 2010·The Journal of Bone and Joint Surgery. British Volume·J M H SmoldersJ L C van Susante
Aug 9, 2011·Bone·Peter J SimmCraig F Munns
Sep 3, 2011·Cleveland Clinic Journal of Medicine·Susan M Ott
Sep 21, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T LinZ-M Ying
Dec 14, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dennis M BlackRichard Eastell
Apr 12, 2012·Acta Orthopaedica·Hannu T AroPetteri Lankinen
Jul 19, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Naoto KamiyaTomohiko Ichikawa
Oct 3, 2012·Clinical Nuclear Medicine·Mana YoshimuraKoichi Tokuuye
Nov 13, 2012·The Journal of Arthroplasty·David F ScottRachel R Smith
Jan 8, 2013·The Journal of Clinical Endocrinology and Metabolism·I R ReidUNKNOWN HORIZON Pivotal Fracture Trial and HORIZON Recurrent Fracture Trial Steering Committees
Jan 18, 2013·The Journal of Bone and Joint Surgery. American Volume·Aasis UnnanuntanaJoseph M Lane
May 29, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth ShaneMichael P Whyte
Apr 8, 2014·The Journal of Arthroplasty·Ashleen R KnustenSophia N Sangiorgio
Citations
Apr 15, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M ShiS Yan
Mar 13, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Long Shao, Xiang-Dong Wu
Jul 21, 2020·Orthopaedic Surgery·Long GongMing-Sheng Tan
May 8, 2019·BioMed Research International·Tsan-Wen HuangHsin-Nung Shih
Aug 21, 2019·Der Unfallchirurg·Carl HaasperThorsten Gehrke
Jul 14, 2019·Spinal Cord·Ricardo A BattaglinoLeslie R Morse
Aug 29, 2019·Orthopaedic Surgery·Guang-Tao FuYue Ding
Sep 30, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K ZhuJ Guan
Oct 21, 2020·The Journal of Bone and Joint Surgery. American Volume·Pablo A SlullitelPaul E Beaulé
Nov 4, 2020·Journal of Orthopaedic Surgery and Research·Guangtao FuQiujian Zheng
Nov 2, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Theofilos S KarachaliosGeorge A Komnos
Nov 13, 2020·Acta Biomaterialia·Mohammed MahriFaleh Tamimi
Jun 19, 2021·Hip & Pelvis·Se-Won LeeHwan-Hee Lee