PMID: 9177872Jun 1, 1997Paper

Bone turnover in neonates: changes of urinary excretion rate of collagen type I cross-linked peptides during the first days of life and influence of gestational age

Bone
S MoraG Chiumello

Abstract

New markers have been used to monitor the changes of bone turnover occurring during growth. Data on bone turnover rate during the perinatal period are, however, very scarce. In the present study we evaluated bone turnover rate, assessed by the measurement of urinary N-terminal telopeptide of type I collagen (NTx) concentrations, at different gestational ages, and we documented the trend of bone turnover rate occurring in the first days after birth. Urine samples were obtained from 83 healthy full term newborn infants, 16 preterm, and 17 infants of diabetic mothers (IDMs). The first miction after birth was collected. Urine samples were also collected 24 and 48 h after birth. NTx was measured by an enzyme-linked immunosorbent assay (Osteomark, Ostex International, Inc. Seattle, WA). The relationship between NTx at birth and all the other variables has been evaluated using multiple regression analysis. The changes of NTx excretion over time and the effect of the groups were studied by multivariate analysis of variance (MANOVA) for repeated measures. We found a remarkable association between gestational age and NTx concentrations at birth (R = 0.56; p < 0.00001). NTx concentrations showed a progressive decrement, reaching a nadir b...Continue Reading

References

Mar 1, 1975·The Journal of Pediatrics·R C TsangT Joyce
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Oct 1, 1990·Archives of Disease in Childhood·P J CongdonH Durward
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Nov 1, 1994·Archives of Pediatrics & Adolescent Medicine·S MoraG Chiumello

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Citations

May 29, 2000·The Proceedings of the Nutrition Society·R Namgung, R C Tsang
Mar 24, 1999·Pediatric Research·K E NaylorG L Klein
Mar 7, 2003·Pediatric Research·Wolfgang HöglerKlaus Kapelari
Sep 24, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Rivka H RegevIta Litmanovitz
Jul 11, 2008·American Journal of Physical Anthropology·Tracy L ProwseLuca Bondioli
Feb 22, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Demetrios GourgiotisAriadne Malamitsi-Puchner
Oct 4, 2005·Acta Paediatrica·Alexandre LapillonneBernard L Salle

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