Bone turnover is reduced in children with juvenile rheumatoid arthritis

Journal of Endocrinological Investigation
F FalciniF Bagnoli

Abstract

Juvenile Rheumatoid Arthritis (JRA) is frequently associated with osteoporosis. In order to determine if JRA osteoporosis is related to reduced formation or to increased bone resorption or both, serum levels of calcium (Ca), phosphorus (PO4), magnesium (Mg), alkaline phosphatase (ALP), parathormone (PTHi), 25-hydroxyvitamin D3 (25-OHD) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D), osteocalcin (OT), carboxyterminal propeptide (P-coll-1-c), and carboxyterminal telopeptide of type I collagen (ICTP) were evaluated in 47 JRA children, 33 with active disease and 14 in remission. The therapy consisted of nonsteroidal antiinflammatory (NSAIDs) drugs in pauciarticular subset, NSAIDs and Methotrexate (MTX) in polyarticular, NSAIDs and steroids in systemic onset. OT reflects bone formation, P-coll-1-c reflects collagen production and bone formation, ICTP, marker of collagen degradation in bone, indicates bone destruction. Serum levels of Ca, PO4, Mg, ALP, PTHi 25-OHD and 1,25-(OH)2D were comparable in JRA children and in controls. OT (8.7 +/- 3.7 ng/ml vs 9.6 +/- 5.1), P-coll-1-c (301.2 +/- 118.4 ng/ml vs 264.1 +/- 100.1) and ICTP (15.7 +/- 5.7 ng/ml vs 16.1 +/- 6.1) did not differ statistically in the whole group of JRA children vs control...Continue Reading

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Citations

Aug 16, 2014·Biomarkers in Medicine·Anne S SiebuhrAnne C Bay-Jensen
Sep 21, 2001·Current Rheumatology Reports·A M Prieur, G Chèdeville
Jan 1, 2008·Reviews in Endocrine & Metabolic Disorders·Anuradha Viswanathan, Francisco A Sylvester
Mar 16, 2011·Journal of Osteoporosis·Kristyna Brabnikova Maresova
May 12, 2005·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·R Cimaz, S Guez
Jan 15, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R V MunekataM O E Hilário
Oct 18, 2001·Current Opinion in Rheumatology·J E McDonagh
Sep 21, 2001·Current Rheumatology Reports·R Cimaz, M Biggioggero
May 18, 2018·Pediatric Rheumatology Online Journal·Sarah L FinchHassan Vatanparast
Oct 17, 2002·Rheumatic Diseases Clinics of North America·Diana S Milojevic, Norman T Ilowite
Dec 15, 2020·Current Rheumatology Reviews·Noha Adel YassinAzza Elhamshary

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