Bone turnover response to changes in calcium intake is altered in girls and adult women in families with histories of osteoporosis

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
K O O'BrienR F Gagel

Abstract

Heredity and environmental factors contribute to the development of osteoporosis. Because calcium is the major mineral in bone and adolescence is a key period in bone acquisition, we hypothesized that bone turnover would be less responsive to alterations in dietary calcium intake in both girls and adult women from families with histories of osteoporosis. To address this issue, we studied calcium kinetics in the maternal grandmother (age range 56-81 years), mother (age range 32-47 years), and granddaughter (age range 8-15 years) in 10 multigenerational families. In five families, the mother and/or grandmother had osteoporosis (bone mineral density > or = 2 SD below the age-specific mean). To examine both active and passive calcium absorption, families consumed low- (279 +/- 64 mg/day) and high- (1580 +/- 385) calcium diets for 10 days prior to administration of oral (46Ca) and intravenous (42Ca) stable isotopes. Using repeated measures analysis of variance, fractional calcium absorption, true calcium absorption, bone calcium deposition, and the balance in bone calcium turnover were all significantly affected by diet (p < 0.01). Females from nonosteoporotic families had decreased bone calcium resorption with little change in bone...Continue Reading

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Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J Skulan, D J DePaolo
Dec 24, 2002·The British Journal of Nutrition·Connie M Weaver, Michael Liebman
Jun 6, 2018·The Journal of Physiology·Kimberly O O'Brien, Steven A Abrams
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