Bones in Multiple Myeloma: Imaging and Therapy

American Society of Clinical Oncology Educational Book
Elena ZamagniDavid Roodman

Abstract

Bone disease is the most frequent disease-defining clinical feature of multiple myeloma (MM), with 90% of patients developing bone lesions over the course of their disease. For this reason, imaging plays a major role in the management of disease in patients with MM. Although conventional radiography has traditionally been the standard of care, its low sensitivity in detecting osteolytic lesions has called for more advanced imaging modalities. In this review, we discuss the advantages, indications, and applications of whole-body low-dose CT (WBLDCT), 18F-fluorodeoxyglucose (FDG)-PET/CT, MRI, and other novel imaging modalities in the management of disease in patients with plasma cell dyscrasias. We also review the state of the art in treatment of MM bone disease (MMBD) and the role of bisphosphonates and denosumab, a monoclonal antibody that binds and blocks the activity of receptor activator of nuclear factor-kappa B ligand (RANKL), which was recently approved by the U.S. Food and Drug Administration for MMBD.

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Citations

Dec 18, 2019·Journal of the National Cancer Institute·Vikram JairamHenry S Park
Mar 12, 2020·AJR. American Journal of Roentgenology·Colin MarshallNikhil H Ramaiya
Apr 30, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Alberto Stefano TagliaficoAlida Dominietto
Jan 27, 2021·Medicina·Alberto Stefano TagliaficoMichele Piana
Jan 28, 2021·AJR. American Journal of Roentgenology·Jonathan M GanNikhil H Ramaiya
Nov 24, 2020·Leukemia & Lymphoma·Georg W HergetMonika Engelhardt
Aug 27, 2019·La Presse médicale·Salomon ManierThierry Facon
Jun 5, 2020·European Journal of Radiology·Hubert BeaumontAntoine Iannessi

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