Booster vaccination against diphtheria and tetanus in man. Comparison of calcium phosphate and aluminium hydroxide as adjuvants--II

Vaccine
H AggerbeckI Heron

Abstract

Diphtheria and tetanus antibody levels were measured before and four weeks after booster vaccination of 313 Danish military recruits participating in a clinical trial to compare aluminium hydroxide and calcium phosphate as adjuvants in diphtheria-tetanus vaccines (DT). Twenty-eight percent of the men had a diphtheria pre-vaccination content below a protective level of 0.01 IU ml-1. The calcium phosphate adsorbed vaccine showed the highest efficacy for both antigens. Adverse reactions were rare but more frequent in the calcium group than in the aluminium group. No correlation was found between pre- or post-vaccination levels and adverse reactions and both vaccines gave rise to specific IgE formation. The results show that calcium phosphate is more effective but not a safer alternative to aluminium hydroxide when compared in vaccines containing 1.0 mg ml-1 of Ca or of Al.

References

Apr 1, 1991·Biologicals : Journal of the International Association of Biological Standardization·H Aggerbeck, I Heron
Jan 7, 1988·The New England Journal of Medicine·R RappuoliE Falsen
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·O SimonsenI Heron
Jul 1, 1986·Journal of Biological Standardization·O SimonsenI Heron
Oct 1, 1984·Archives of Dermatology·H A Fawcett, N P Smith
May 1, 1980·Reviews of Infectious Diseases·R Edelman
Jan 1, 1993·Vaccine·R K GuptaC K Gupta
Aug 6, 2003·Expert Review of Vaccines·Gregory Glenn
Jul 1, 1955·The Journal of Experimental Medicine·R G WHITEJ M CONNOLLY
Jul 1, 1942·American Journal of Public Health and the Nation's Health·V K Volk, W E Bunney

❮ Previous
Next ❯

Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·R K Gupta
Feb 12, 2004·The Lancet Infectious Diseases·Tom JeffersonCarlo Di Pietrantonj
Dec 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·O SimonsenI Heron
Feb 16, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·C GrüberB Björkstén
Dec 17, 2014·The Journal of Pharmacy and Pharmacology·Charlotte N MaughanGareth R Williams
Oct 4, 2016·Expert Review of Vaccines·Jean-Daniel MassonGuillemette Crépeaux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.