Booster vaccination against diphtheria and tetanus in man. Comparison of three different vaccine formulations--III

Vaccine
H AggerbeckI Heron

Abstract

Adverse reactions and antibody levels were compared following a booster vaccination of 177 Danish military recruits with a plain, an aluminium hydroxide (0.5 mg Al per human dose, HD) and a calcium phosphate (0.25 mg Ca per HD) adsorbed diphtheria-tetanus (D-T) vaccine. The calcium phosphate adsorbed vaccine was given in a HD of 3 Lf of D and T toxoids and proved to be of equal efficacy as the aluminium hydroxide adsorbed vaccine which was injected in a dose containing twice the antigen amount. The calcium phosphate vaccine caused fewer adverse reactions than the one adsorbed to aluminium hydroxide. The plain vaccine (6 Lf per HD of D and T toxoid) had the highest efficacy with a similar low occurrence of adverse reactions as the calcium phosphate adsorbed vaccine. Potency assays in mice were in accordance with these immunogenicity results in man if a two dose immunization schedule was followed, but not if the vaccines were compared after a single immunization as requested by the procedure for potency testing according to current WHO and European Pharmacopoeia requirements. Both of the adsorbed vaccines primed mice for specific IgE antibody formation. This could be detected after a second immunization with either of the adsorbe...Continue Reading

References

Apr 1, 1991·Biologicals : Journal of the International Association of Biological Standardization·H Aggerbeck, I Heron
Jun 1, 1973·The Journal of Hygiene·W G WhiteJ W Smith
Feb 1, 1995·European Journal of Epidemiology·A M Galazka, S E Robertson
Feb 1, 1995·European Journal of Epidemiology·A M GalazkaG P Oblapenko

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Citations

Aug 3, 2001·Vaccine·P MoingeonA Lindberg
Feb 5, 2000·The Journal of Infectious Diseases·T RønneP Ricks
Feb 23, 2013·TheScientificWorldJournal·Shinobu WataraiKenji Kono
Jul 25, 2014·Japanese Journal of Infectious Diseases·Tetsuya Uchida, Maiko Taneichi
Oct 4, 2007·International Journal of Dermatology·Kabir SardanaSuvasini Sharma
Jul 5, 2015·Toxicon : Official Journal of the International Society on Toxinology·Ivana LukićMarijana Stojanović
Dec 24, 2010·Microbiology and Immunology·Tetsuya Uchida
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maiko TaneichiTetsuya Uchida

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