Boosting immune response with a candidate varicella-zoster virus glycoprotein subunit vaccine

Vaccine
A Vafai

Abstract

A varicella-zoster virus (VZV) seropositive individual was immunized with 100 micrograms of purified VZV TgpI-511 glycoprotein subunit antigen formulated with monophosphoryl lipid A. Serum samples were obtained during a 40-day period post-immunization (PI) and analysed by immunoprecipitation and virus neutralization tests. The results from immunoprecipitation studies revealed an increase in VZV anti-gpI antibody titer as early as 6 days PI which continued to rise during 40 days PI. In addition, virus neutralization tests showed a 21.0% VZV neutralization 6 days PI with an increase to a 96.7% VZV neutralization 40 days PI. These results suggested that the candidate VZV glycoprotein subunit vaccine (TgpI-511) was capable of boosting the production of neutralizing antibodies in the immunized VZV seropositive human subject.

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Citations

Nov 6, 2014·The Journal of Infectious Diseases·Elchonon M BerkowitzUNKNOWN Zoster-015 HZ/su Study Group
Feb 13, 2016·Expert Opinion on Biological Therapy·Anthony L Cunningham
Aug 5, 2000·Mayo Clinic Proceedings·T J Liesegang
Apr 29, 2015·The New England Journal of Medicine·Himal LalUNKNOWN ZOE-50 Study Group
Jun 22, 2001·The American Journal of the Medical Sciences·A Vafai, M Berger
May 11, 2017·Expert Review of Vaccines·Anthony L Cunningham, Thomas Heineman
Apr 17, 2001·Infectious Disease Clinics of North America·D C Molrine, P L Hibberd
Mar 13, 2018·The Journal of Infectious Diseases·Anthony L CunninghamUNKNOWN ZOE-50/70 Study Group
Jul 22, 2018·Expert Review of Vaccines·Nicolas LecrenierAlain Brecx
Sep 25, 2018·The Journal of Infectious Diseases·Anthony L Cunningham, Myron J Levin
Feb 24, 2021·BMJ : British Medical Journal·Anthony L CunninghamMyron J Levin

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