Boosting of activity enhancement of K(+)-responsive quadruplex hammerhead ribozyme

Chemical Communications : Chem Comm
Yudai YamaokiMasato Katahira

Abstract

Two second-generation quadruplex hammerhead ribozymes, whose activity enhances in response to K(+)via quadruplex formation of embedded r(GGA)3GG, were developed. Different strategies were applied to suppress basal activity when K(+) is absent. As a result, the activity enhancement upon the addition of K(+) has reached as high as 21-fold.

References

Jun 25, 1992·Nucleic Acids Research·K J HertelR Hodgson
Aug 13, 1987·Nature·O C Uhlenbeck
Feb 1, 1997·Journal of Biochemistry·T SakamotoS Uesugi
Jun 11, 1999·Current Opinion in Structural Biology·D E Gilbert, J Feigon
May 23, 2002·Biochemistry·Donald H BurkeMarit Nilsen-Hamilton
May 23, 2006·Current Opinion in Structural Biology·Anh Tuân PhanDinshaw J Patel
Jul 28, 2006·Angewandte Chemie·Markus Wieland, Jörg S Hartig
Oct 3, 2006·Nucleic Acids Research·Sarah BurgeStephen Neidle
Aug 25, 2007·Chemical Reviews·Michael FamulokGünter Mayer
Dec 7, 2007·Biotechnology & Genetic Engineering Reviews·Maung Nyan Win, Christina D Smolke
May 6, 2008·RNA·Jean-Denis Beaudoin, Jean-Pierre Perreault
Jul 8, 2008·Chembiochem : a European Journal of Chemical Biology·Markus Wieland, Jörg S Hartig
Aug 23, 2008·Nucleic Acids Research·Andrew N LaneJohn O Trent
Aug 12, 2009·Nucleic Acids Research·Tsukasa MashimaMasato Katahira
Nov 28, 2012·Nucleic Acids Research·Tsukasa MashimaMasato Katahira

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