Boosting the Detection Potential of Liquid Chromatography-Electron Ionization Mass Spectrometry Using a Ceramic Coated Ion Source

Journal of the American Society for Mass Spectrometry
Laura MagriniAchille Cappiello

Abstract

Detection of target and non-target substances and their characterization in complex samples is a challenging task. Here we demonstrate that coating the electron ionization (EI) ion source of an LC-MS system with a sol-gel ceramic film can drastically improve the detection of high-molecular weight and high-boiling analytes. A new ion source coated with a ceramic material was developed and tested with a mixture of polycyclic aromatic hydrocarbons (PAH) with an increasing number of rings. Comparison of the results obtained with those for an uncoated stainless steel (SS) ion source shows a dramatic improvement in the MS signals, with a nearly 40-fold increase of the signal-to-noise ratio. We also demonstrate the ability of the new system to produce excellent chromatographic profiles for hard-to-detect hormones. Graphical Abstract ᅟ.

References

Mar 10, 2011·Mass Spectrometry Reviews·Achille CappielloHelga Trufelli
Apr 19, 2011·Mass Spectrometry Reviews·Helga TrufelliAchille Cappiello
May 28, 2011·Analytical and Bioanalytical Chemistry·Helga TrufelliAchille Cappiello
Jun 20, 2013·Journal of Chromatographic Science·Jochen J Brocks, Janet M Hope

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Citations

Oct 17, 2015·Journal of the American Society for Mass Spectrometry·Veronica TermopoliChris G Gill
Sep 13, 2016·Journal of Proteome Research·Sujun LiJames P Reilly
Jan 24, 2020·The Analyst·Marco Beccaria, Deirdre Cabooter
Jun 1, 2018·Journal of Analytical Methods in Chemistry·Federica BianchiMaria Careri
Jun 10, 2017·Analytica Chimica Acta·Nicolò RiboniAchille Cappiello
May 30, 2021·Analytica Chimica Acta·Giorgio FamigliniAchille Cappiello

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