Bopindolol: pharmacological basis and clinical implications

Cardiovascular Drug Reviews
T NagatomoM Ishiguro

Abstract

Bopindolol, a non-selective antagonist of beta 1- and beta 2-adrenoceptors (ARs), has been found by pharmacological, molecular biological techniques and molecular modeling to have several unique properties. Bopindolol produces sustained blockade of beta 1- and beta 2-ARs, has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Also, our recent molecular modeling studies identified possible interaction sites between bopindolol and beta-AR subtypes. The reviewed studies support our findings that bopindolol is non-selective for beta 1- and beta 2-ARs, has low affinity for beta 3-AR subtype and has pharmacological properties that are likely to be beneficial in the treatment of cardiovascular diseases.

References

Jan 1, 1992·Annual Review of Pharmacology and Toxicology·J OstrowskiR J Lefkowitz
Mar 24, 1992·European Journal of Pharmacology·Y NasaY Abiko
Sep 8, 1989·Science·L J EmorineA D Strosberg
Aug 1, 1989·Trends in Pharmacological Sciences·A J Kaumann
Feb 1, 1989·Trends in Pharmacological Sciences·P R Hartig
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T FrielleB K Kobilka
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A H van den MeirackerM A Schalekamp
Jan 1, 1985·European Journal of Clinical Pharmacology·J R Cove-Smith, C A Kirk
Jul 1, 1984·Clinical Pharmacology and Therapeutics·R PlatzerJ Rosenthaler
Jul 1, 1995·Japanese Journal of Pharmacology·Y AniyaM Sakanashi
Mar 1, 1993·General Pharmacology·H TanakaK Shigenobu
Aug 1, 1995·Biological & Pharmaceutical Bulletin·Y HosohataT Nagatomo
Nov 22, 1997·European Journal of Pharmacology·K KoikeT Nagatomo
Nov 27, 1998·Journal of Autonomic Pharmacology·S A Doggrell, C J Henderson
Sep 19, 1964·British Medical Journal·B N PRICHARD, P M GILLAM

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