Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Chi-Tun RuanMing-Jai Su

Abstract

Diabetes mellitus (DM) often leads to disability from vascular complications and neurological complications. Tinospora crispa has been widely used in Asia and Africa as a remedy for diabetes and other diseases. In this study, we investigated the hypoglycemic actions of borapetoside C isolated from T. crispa, and the mechanisms underlying its actions. Acute treatment with borapetoside C (5mg/kg, i.p.) attenuated the elevated plasma glucose induced by oral glucose in normal and type 2 DM (T2DM) mice. Compared to the effect of injected insulin (0.5 IU/kg), borapetoside C caused a more prominent increase of glycogen content in skeletal muscle of T2DM mice, but a less increase in type 1 DM (T1DM) mice. Combined treatment of a low dose borapetoside C (0.1mg/kg, i.p.) plus insulin enhanced insulin-induced lowering of the plasma glucose level and insulin-induced increase of muscle glycogen content. Continuous treatment with 5mg/kg borapetoside C (twice daily) for 7 days increased phosphorylation of insulin receptor (IR) and protein kinase B (Akt) as well as the expression of glucose transporter-2 (GLUT2) in T1DM mice. Combined treatment of a low dose borapetoside C (0.1mg/kg, twice daily) plus insulin for 7 days enhanced insulin-induce...Continue Reading

References

Nov 1, 1989·Journal of Ethnopharmacology·H Noor, S J Ashcroft
May 1, 1996·Phytochemistry·T S MartinK Yamasaki
Sep 25, 1999·The Journal of Biological Chemistry·L LavoieB I Posner
Apr 29, 2000·Journal of Natural Products·C Y RagasaJ A Rideout
Jul 21, 2000·The Journal of Clinical Investigation·G I Shulman
Dec 14, 2001·Biochemical and Biophysical Research Communications·M HosokawaB Thorens
Nov 5, 2002·Journal of Ethnopharmacology·Ngampong KongkathipSom Hatthakitpanichakul
Nov 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Peter Vollenweider
Aug 13, 2005·Journal of Ethnopharmacology·Sang Hyun ParkSung Hyun Chung
Jun 7, 2006·Biological & Pharmaceutical Bulletin·Koji HayashiMikio Ito
Jan 27, 2007·Planta medica·A CavinO Potterat
May 1, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Mark C GranberryAmy M Franks
May 12, 2007·International Journal of Clinical Practice·H E BaysUNKNOWN SHIELD Investigators' Group
Jan 6, 2009·The American Journal of Medicine·Harold E Bays
Apr 2, 2010·Journal of Natural Products·M Iqbal Choudhary Atta-ur-Rahman
Sep 2, 2010·Journal of Agricultural and Food Chemistry·Yi-Chun WengMing-Jai Su
Jan 31, 2012·Journal of Natural Products·Sio-Hong LamShoei-Sheng Lee

❮ Previous
Next ❯

Citations

Mar 26, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chi-Tun RuanMing-Jai Su
Jan 11, 2016·Phytotherapy Research : PTR·Alex ThomasD Suresh Kumar
Mar 5, 2013·Molecular Nutrition & Food Research·Isabel Cordero-HerreraSonia Ramos
Apr 16, 2014·The Journal of Pharmacy and Pharmacology·Mohamed EddouksNaoufel Ali Zeggwagh
Dec 10, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Faradianna E LokmanClaes-Göran Ostenson
May 23, 2015·Bioorganic & Medicinal Chemistry·Chi-Chih ChangShoei-Sheng Lee
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Mohd Nazri AbuHamzah Fansuri Hassan
Jun 28, 2014·BMC Complementary and Alternative Medicine·Walaa Najm AboodSalmah Ismail
Sep 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Sensen ChiBin Liu
Oct 27, 2016·Natural Products and Bioprospecting·Yuan GaoJi-Kai Liu
Jun 24, 2017·Bioorganic & Medicinal Chemistry Letters·Wenlong SunYuesheng Dong
Apr 8, 2016·Molecular Medicine Reports·Guoqiang LiangGuorong Jiang
Nov 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Gabriela Diniz Pinto CoelhoReggiani Vilela Gonçalves
Jul 3, 2020·Current Pharmaceutical Design·Mervin Chávez-CastilloValmore Bermúdez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Chi-Tun RuanMing-Jai Su
Journal of Natural Products
Sio-Hong LamShoei-Sheng Lee
Journal of Biomedicine & Biotechnology
Theerawut Klangjareonchai, Chulaporn Roongpisuthipong
Journal of Ethnopharmacology
N Najib Nik A RahmanM Ali Mohd
Journal of Ethnopharmacology
H Noor, S J Ashcroft
© 2021 Meta ULC. All rights reserved