Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

Nature Immunology
Gregory F SonnenbergDavid Artis

Abstract

The maintenance of barrier function at exposed surfaces of the mammalian body is essential for limiting exposure to environmental stimuli, preventing systemic dissemination of commensal and pathogenic microbes and retaining normal homeostasis of the entire body. Indeed, dysregulated barrier function is associated with many infectious and inflammatory diseases, including psoriasis, influenza, inflammatory bowel disease and human immunodeficiency virus, which collectively afflict millions of people worldwide. Studies have shown that interleukin 22 (IL-22) is expressed at barrier surfaces and that its expression is dysregulated in certain human diseases, which suggests a critical role in the maintenance of normal barrier homeostasis. Consistent with that, studies of mouse model systems have identified a critical role for signaling by IL-22 through its receptor (IL-22R) in the promotion of antimicrobial immunity, inflammation and tissue repair at barrier surfaces. In this review we will discuss how the expression of IL-22 and IL-22R is regulated, the functions of the IL-22-IL-22R pathway in regulating immunity, inflammation and tissue homeostasis, and the therapeutic potential of targeting this pathway in human disease.

References

Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L DumoutierJ C Renauld
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·L DumoutierJ C Renauld
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L DumoutierJ C Renauld
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S V KotenkoS Pestka
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·W XuD C Foster
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin WolkRobert Sabat
Jan 7, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Naomi J LogsdonMark R Walter
Mar 23, 2004·Annual Review of Immunology·Sidney PestkaPaul B Fisher
May 4, 2004·International Immunopharmacology·Jing LiLynette A Fouser
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Svetlana RadaevaBin Gao
Aug 17, 2004·Immunity·Kerstin WolkRobert Sabat
Nov 13, 2004·The New England Journal of Medicine·Peter J MannonUNKNOWN Anti-IL-12 Crohn's Disease Study Group
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katia BonifaceFranck Morel
Apr 9, 2005·Arthritis and Rheumatism·Hidekazu IkeuchiYoshihisa Nojima
Mar 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan BrandJulia Dambacher
Sep 20, 2006·The Journal of Experimental Medicine·Spencer C LiangLynette A Fouser
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin WolkRobert Sabat
Aug 7, 2007·Nature Immunology·Nicholas J WilsonRene de Waal Malefyt
Sep 21, 2007·The New England Journal of Medicine·Steven M HollandBodo Grimbacher
Sep 29, 2007·Clinical and Experimental Immunology·K BonifaceF Morel
Oct 20, 2007·HIV Medicine·F BonnetUNKNOWN Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Spencer C LiangLynette A Fouser
Dec 7, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Houjun LiuYating Tu
Feb 12, 2008·Nature Medicine·Shean J AujlaJay K Kolls
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jérôme PèneHugues Gascan
Jul 2, 2008·The Journal of Experimental Medicine·Cindy S MaMatthew C Cook
Jul 23, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charlotte LewdenUNKNOWN ANRS EN19 Mortalité Study Group and Mortavic1

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Citations

Feb 24, 2012·Inflammatory Bowel Diseases·Atsushi Mizoguchi
Sep 29, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Govardhana Rao YannamLarisa Y Poluektova
Oct 15, 2013·Immunology Letters·Enrico VelardiMarcel R M van den Brink
May 7, 2013·Trends in Immunology·Yasmine BelkaidTimothy W Hand
May 15, 2013·Journal of Dermatological Science·Hidehisa SaekiMayumi Tamari
Jun 12, 2013·Journal of Dermatological Science·Hideki Fujita
Jul 3, 2013·Microbes and Infection·Paras K Anand, Thirumala-Devi Kanneganti
Jan 23, 2013·Immunology and Cell Biology·Naomi H Philip, David Artis
Sep 14, 2012·Nature·Craig L MaynardCasey T Weaver
May 24, 2013·Nature·Matthew R HepworthGregory F Sonnenberg
Jan 24, 2012·Nature Reviews. Immunology·Susan L SwainTara M Strutt
Jun 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Carlene L ZindlCasey T Weaver
Jul 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Timothy L Denning, Charles A Parkos
Dec 16, 2011·The Journal of Biological Chemistry·Ina RudloffHeiko Mühl
Dec 5, 2012·The Journal of Experimental Medicine·Giuseppe SciuméJohn J O'Shea
Mar 3, 2012·Science·Jarrod A DudakovMarcel R M van den Brink
Aug 30, 2011·Blood·Andrew E ArmitageHal Drakesmith
Jul 4, 2012·Journal of Leukocyte Biology·Juan L Rendon, Mashkoor A Choudhry
Oct 11, 2012·PLoS Biology·Jerry R McGhee, Kohtaro Fujihashi
Mar 3, 2012·PloS One·Shabnam ShalapourThomas Schüler
Jul 26, 2012·PloS One·Martin J WolffP'ng Loke
Sep 7, 2012·PloS One·Penghua WangErol Fikrig

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