Bordetella pertussis culture having only species factor 1.

Journal of Bacteriology
G ElderingJ Baker

Abstract

Eldering, Grace (Michigan Department of Public Health, Grand Rapids), Jack Holwerda, and Julia Baker. Bordetella pertussis culture having only species factor 1. J. Bacteriol. 91:1759-1762. 1966.-Preston's description of Bordetella pertussis 353-Z as a culture possessing only factor 1 was confirmed by agglutination and agglutinin-adsorption tests. The ld(50) values of this culture for mice inoculated by the intracerebral route were approximately the same as that of B. pertussis 18-323, the challenge culture in mouse potency tests of pertussis vaccine. In mouse protection tests, vaccine prepared with the factor 1 culture protected as well against challenge with B. pertussis 18-323, which has a broad antigenic pattern, as did vaccines made with cultures possessing factors 2, 3, 4, and 5 in addition to factor 1. When two groups of similarly immunized mice were challenged with 353-Z and 18-323, respectively, much lower ed(50) values were obtained with the animals challenged with 353-Z. This was true whether a factor 1 vaccine or a vaccine with factors 1, 2, 3, 4, and 5 was tested.

References

Jan 1, 1953·Acta Pathologica Et Microbiologica Scandinavica·E K ANDERSEN
Aug 1, 1957·Journal of Bacteriology·G ELDERINGJ BAKER
Jan 1, 1958·Acta Pathologica Et Microbiologica Scandinavica·E K ANDERSEN, M W BENTZON
Jul 3, 1965·British Medical Journal·N W PRESTON
Jul 1, 1931·The Journal of Hygiene·P H Leslie, A D Gardner

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Citations

Apr 1, 1976·The Journal of Hygiene·N W Preston, T N Stanbridge
Sep 1, 1969·Japanese Journal of Microbiology·Y NakaseT Kasuga
Apr 10, 1971·The Medical Journal of Australia·A C BlaskettL C Fulton
Mar 1, 1985·Vaccine·A RobinsonL A Ashworth
Jun 1, 1967·Journal of Bacteriology·G ElderingJ Baker
Oct 1, 1969·Applied Microbiology·G ElderingJ Baker

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