Bordetella pertussis does not induce beta-adrenergic blockade.

Infection and Immunity
E L HewlettC R Manclark

Abstract

Bordetella pertussis organisms induce histamine sensitivity and diminish the normal hyperglycemic response to epinephrine in experimental animals. These effects have been attributed to beta-adrenergic blockade. However, under conditions in which the decrease in epinephrine-induced hyperglycemia after B. pertussis administration was demonstrable, there was no change in rat reticulocyte beta-adrenergic receptor number or affinity measured by iodohydroxybenzylpindolol binding or in isoproterenol-stimulated adenylate cyclase activity. Therefore, there was no generalized beta-adrenergic blockade induced by B. pertussis. The observed effects can be explained by the hypersecretion of insulin resulting from B. pertussis administration.

References

Jun 1, 1976·The Journal of Experimental Medicine·S I Morse, J H Morse
Apr 1, 1973·The Journal of Experimental Medicine·C W Parker, S I Morse
Oct 1, 1968·Endocrinology·A GulbenkianI I Tabachnick
Feb 1, 1966·The Journal of Clinical Investigation·D PorteR H Williams

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