PMID: 9529111Apr 7, 1998Paper

Bordetella pertussis filamentous hemagglutinin enhances the immunogenicity of liposome-delivered antigen administered intranasally

Infection and Immunity
O Poulain-GodefroyGilles Riveau

Abstract

In an attempt to increase the immunogenicity of mucosally delivered antigens, we incorporated the Bordetella pertussis filamentous hemagglutinin (FHA) adhesin into liposomes containing the glutathione S-transferase of Schistosoma mansoni (Sm28GST) as a model antigen. Outbred mice immunized twice intranasally with liposomes containing a constant suboptimal dose of Sm28GST and increasing doses of FHA produced anti-Sm28GST antibodies in a FHA dose-dependent manner. The addition of 3 microg of FHA to the liposomes induced more than 10-fold-higher anti-Sm28GST antibody titers, compared to those induced by liposomes without FHA. The presence of FHA did not alter the nature of the humoral immune response, and the sera contained anti-Sm28GST immunoglobulin G1 (IgG1), IgG2a, and IgG2b. However, anti-Sm28GST IgA was only detected when at least 3 microg of FHA was added to the preparation. These results show a promising potential for FHA to enhance the immunogenicity of mucosally administered antigens incorporated into liposomes.

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Citations

Nov 18, 1998·Journal of Microencapsulation
Nov 25, 2003·Scandinavian Journal of Immunology·O Poulain-GodefroyG Riveau
May 9, 2014·Clinical and Vaccine Immunology : CVI·Carolina Salcedo-RivillasMaria Leonor S Oliveira
Oct 30, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hossein Asgarian-OmranFazel Shokri
Feb 12, 2004·Scandinavian Journal of Immunology·S CornélieG Riveau
Jan 28, 2017·Journal of Immunology Research·Valentina BernasconiNils Y Lycke
Dec 26, 2001·Pharmaceutical Science & Technology Today·C Locht
Aug 23, 2001·Advanced Drug Delivery Reviews·S S Davis

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