Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines

Microbial Genomics
Aldert ZomerJeroen Geurtsen

Abstract

Bordetella pertussis, the causative agent of whooping cough, has experienced a resurgence in the past 15 years, despite the existence of both whole-cell and acellular vaccines. Here, we performed whole genome sequencing analysis of 149 clinical strains, provided by the National Institute of Infectious Diseases (NIID), Japan, isolated in 1982-2014, after Japan became the first country to adopt acellular vaccines against B. pertussis. Additionally, we sequenced 39 strains provided by the Konan Kosei Hospital in Aichi prefecture, Japan, isolated in 2008-2013. The genome sequences afforded insight into B. pertussis genome variability and population dynamics in Japan, and revealed that the B. pertussis population in Japan was characterized by two major clades that divided more than 40 years ago. The pertactin gene was disrupted in about 20 % of the 149 NIID isolates, by either a deletion within the signal sequence (ΔSS) or the insertion of IS element IS481 (prn :: IS481). Phylogeny suggests that the parent clones for these isolates originated in Japan. Divergence dating traced the first generation of the pertactin-deficient mutants in Japan to around 1990, and indicated that strains containing the alternative pertactin allele prn2 m...Continue Reading

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Citations

Jul 23, 2019·Journal of Medical Microbiology·Ikram Ben FrajSylvain Brisse
May 21, 2021·Emerging Infectious Diseases·Longhuan MaEric T Harvill
Oct 5, 2021·Frontiers in Immunology·Francisco CarriquiribordeDaniela F Hozbor

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Datasets Mentioned

BETA
PRJEB18624

Methods Mentioned

BETA
ELISA

Software Mentioned

FASTQC
Snippy
SPAdes
beast
Tracer
blast
Illumina Casava
CLC Genomics Workbench
BaseClear
Parsnp

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