BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours

British Journal of Cancer
Vivien D'ArcyElena M Klenova

Abstract

BORIS (for brother of the regulator of imprinted sites), a paralogue of the transcription factor, CTCF, is a novel member of the cancer-testis antigen family. The aims of the present study were as follows: (1) to investigate BORIS expression in breast cells and tumours using immunohistochemical staining, western and real-time RT-PCR analyses and (2) assess potential correlation between BORIS levels in tumours with clinical/pathological parameters. BORIS was detected in all 18 inspected breast cell lines, but not in a primary normal breast cell culture. In 70.7% (41 of 58 cases) BORIS was observed in breast tumours. High levels of BORIS correlated with high levels of progesterone receptor (PR) and oestrogen receptor (ER). The link between BORIS and PR/ER was further confirmed by the ability of BORIS to activate the promoters of the PR and ER genes in the reporter assays. Detection of BORIS in a high proportion of breast cancer patients implies potential practical applications of BORIS as a molecular biomarker of breast cancer. This may be important for diagnosis of the condition and for the therapeutic use of BORIS. The ability of BORIS to activate promoters of the RP and ER genes points towards possible involvement of BORIS in ...Continue Reading

References

Aug 1, 1987·Molecular and Cellular Biology·C Chen, H Okayama
Jan 1, 1982·Cell and Tissue Research·E V Gaffney
Apr 1, 1995·Molecular and Cellular Biology·E C deConinckR J Weigel
Oct 27, 1999·Genes, Chromosomes & Cancer·S CuthillC A Reznikoff
Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·A A JungbluthL J Old
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Martin JanzHans-Dieter Royer
Aug 23, 2002·Seminars in Cancer Biology·Elena M KlenovaVictor V Lobanenkov
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Immaculata De VivoDavid J Hunter
Sep 19, 2002·International Journal of Cancer. Journal International Du Cancer·Angela BarrettJoyce Taylor-Papadimitriou
Nov 26, 2002·Immunological Reviews·Matthew J ScanlanYao-Tseng Chen
Jul 9, 2004·World Journal of Gastroenterology : WJG·Li ZhaoJi-Ye Zhu
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dhananjay A ChitaleRobert A Soslow
Feb 18, 2005·Cancer Cell International·Martins Kalejs, Jekaterina Erenpreisa
Sep 21, 2005·Endocrine-related Cancer·Daniel Medina
Jun 24, 2006·Journal of Leukocyte Biology·Nadja E Tobler, Michael Detmar
Jul 21, 2006·Biochemical Pharmacology·Michèle J HoffmannWolfgang A Schulz
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vivien D'ArcyElena Klenova
Dec 21, 2006·The Journal of Pathology·P Jelinic, P Shaw
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anahit GhochikyanMichael G Agadjanyan
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John Ian RisingerJ Carl Barrett
Apr 6, 2007·Cancer Immunology, Immunotherapy : CII·Jean-Philippe TheurillatHolger Moch
Nov 7, 2007·Clinical & Experimental Metastasis·Suzanne EcclesJonathan Sleeman

❮ Previous
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Citations

Feb 5, 2014·Immunotherapy·Soudeh Ghafouri-FardSanaz Tabarestani
Jun 15, 2014·Acta Biochimica Et Biophysica Sinica·Sara SoltanianAhmad Reza Bahrami
Nov 17, 2010·PloS One·Elena M PugachevaVictor Lobanenkov
Aug 4, 2011·PloS One·Tania A JonesDenise Sheer
Jan 10, 2012·The Journal of Biological Chemistry·Adar MakovskiUri Nir
Jun 23, 2012·PloS One·Manuel Rosa-GarridoAlberto Gandarillas
Jan 1, 2013·Cell Regeneration·Alexander Strunnikov
Dec 15, 2012·Genetic Testing and Molecular Biomarkers·Kefei ChenYang Qin
Nov 26, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Michèle Amouyal
Sep 23, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Adele Murrell
Aug 19, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Félix Recillas-TargaErnesto Soto-Reyes
Dec 16, 2011·Journal of Translational Medicine·Rosalia de Necochea-CampionEwa Carrier
Oct 23, 2012·International Reviews of Immunology·Apurva PandeyNatalia Platonova
Nov 28, 2013·BMC Cell Biology·Babatunji W OgunkoladeDenise Sheer
Mar 10, 2017·Cancer Letters·Yongfei LiYongmei Yin
Jul 2, 2014·Biochimica Et Biophysica Acta·Michele ZampieriPaola Caiafa
Oct 15, 2013·The Prostate·Zubair CheemaElena Klenova
Nov 21, 2009·The Journal of Pathology·Elliott Lever, Denise Sheer
Dec 19, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Rolf OhlssonElena Klenova
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Smriti SinghSanjeev Shukla
Sep 11, 2014·The Korean Journal of Thoracic and Cardiovascular Surgery·Hae Young LeeSang Bong Jung
Feb 25, 2014·Pathology Oncology Research : POR·Renata Novak KujundžićKoraljka Gall Trošelj
Nov 29, 2017·Oncology Letters·Yanmei ZhangXiaoju Wang
Sep 18, 2020·Nucleic Acids Research·Yuliang Feng, Siim Pauklin
Apr 6, 2011·Journal of Cellular Physiology·Francesco Paolo Fiorentino, Antonio Giordano
Oct 17, 2018·Cancer Cell International·Sara Soltanian, Hesam Dehghani
Aug 14, 2019·Oncogenesis·Marisol Salgado-AlbarránErnesto Soto-Reyes
May 13, 2020·Genome Biology·Mayilaadumveettil NishanaJane A Skok
Mar 22, 2014·Biomedical Reports·Eduardo Portillo Del CampoMiguel Reyes-Romero
Nov 6, 2018·Cancer Immunology, Immunotherapy : CII·Dmitri Loukinov
Sep 16, 2008·Médecine sciences : M/S·Sophie RousseauxSaadi Khochbin

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Datasets Mentioned

BETA
DQ778128
DQ778127

Methods Mentioned

BETA
transfections
Assay
transfection
PCR
immunoprecipitation

Software Mentioned

Image J

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