Born This Way: Using Intrinsic Disorder to Map the Connections between SLITRKs, TSHR, and Male Sexual Orientation

Proteomics
Tara BasavanhallyVladimir N Uversky

Abstract

Recently, genome-wide association study reveals a significant association between specific single nucleotide polymorphisms (SNPs) in men and their sexual orientation. These SNPs (rs9547443 and rs1035144) reside in the intergenic region between the SLITRK5 and SLITRK6 genes and in the intronic region of the TSHR gene and might affect functionality of SLITRK5, SLITRK6, and TSHR proteins that are engaged in tight control of key developmental processes, such as neurite outgrowth and modulation, cellular differentiation, and hormonal regulation. SLITRK5 and SLITRK6 are single-pass transmembrane proteins, whereas TSHR is a heptahelical G protein-coupled receptor (GPCR). Mutations in these proteins are associated with various diseases and are linked to phenotypes found at a higher rate in homosexual men. A bioinformatics analysis of SLITRK5, SLITRK6, and TSHR proteins is conducted to look at their structure, protein interaction networks, and propensity for intrinsic disorder. It is assumed that this information might improve understanding of the roles that SLITRK5, SLITRK6, and TSHR play within neuronal and thyroidal tissues and give insight into the phenotypes associated with male homosexuality.

References

May 29, 1992·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Nov 5, 1999·Journal of Molecular Biology·P E Wright, H J Dyson
Nov 28, 2000·Proteins·P RomeroA K Dunker
Feb 13, 2001·Endocrinology·P CrisantiB Saunier
May 31, 2001·Journal of Molecular Graphics & Modelling·A K DunkerZ Obradovic
Sep 5, 2001·Nature Biotechnology·A K Dunker, Z Obradovic
Dec 26, 2001·Current Opinion in Structural Biology·B Kobe, A V Kajava
Jan 11, 2002·European Journal of Biochemistry·Vladimir N Uversky
Feb 13, 2002·Current Opinion in Structural Biology·H Jane Dyson, Peter E Wright
Mar 23, 2002·Protein Science : a Publication of the Protein Society·Vladimir N Uversky
May 23, 2002·Biochemistry·A Keith DunkerZoran Obradović
Oct 9, 2002·Trends in Biochemical Sciences·Peter Tompa
Nov 7, 2002·Advances in Protein Chemistry·A Keith DunkerZoran Obradovic
Oct 11, 2003·Molecular and Cellular Neurosciences·Jun Aruga, Katsuhiko Mikoshiba
Oct 28, 2003·Proteins·Zoran ObradovicA Keith Dunker
Feb 13, 2004·Nucleic Acids Research·Lilia M IakouchevaA Keith Dunker
Mar 9, 2004·Trends in Biochemical Sciences·Gilbert VassartSabine Costagliola
Apr 3, 2004·Genome Biology·Craig E NelsonSean B Carroll
May 27, 2004·Proteins·Maxim ShatskyHaim J Wolfson
Aug 12, 2004·The Journal of Biological Chemistry·William R MoyleMichael P Bernard
Aug 26, 2004·Journal of Molecular Biology·Tetsuji OkadaVolker Buss
Oct 19, 2004·Trends in Immunology·Alexander B Sigalov
Jan 13, 2005·Human Genetics·Brian S MustanskiDean H Hamer
Jan 15, 2005·Thyroid : Official Journal of the American Thyroid Association·Ricardo Núñez MiguelJadwiga Furmaniak
Feb 9, 2005·Biochemistry·Christopher J OldfieldA Keith Dunker
Feb 22, 2005·The Journal of Biological Chemistry·Eneko UrizarLeonardo Pardo
Mar 2, 2005·Nature Reviews. Molecular Cell Biology·H Jane Dyson, Peter E Wright
Mar 8, 2005·Journal of Bioinformatics and Computational Biology·Kang PengZoran Obradovic
Aug 2, 2005·Trends in Biochemical Sciences·Peter TompaLászló Buday
Aug 12, 2005·Journal of Molecular Recognition : JMR·Vladimir N UverskyA Keith Dunker
Sep 15, 2005·Biochemistry·Christopher J OldfieldA Keith Dunker
Oct 13, 2005·The FEBS Journal·A Keith DunkerVladimir N Uversky
Dec 31, 2005·Nucleic Acids Research·Chris StarkMike Tyers
Apr 19, 2006·BMC Bioinformatics·Kang PengZoran Obradovic
Aug 29, 2006·Journal of Molecular Biology·Amrita MohanVladimir N Uversky
Dec 13, 2006·Biophysical Journal·Predrag RadivojacA Keith Dunker
Mar 28, 2007·Bioinformatics·Monika FuxreiterIstván Simon
May 10, 2007·Journal of Proteome Research·Vladimir VacicA Keith Dunker

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.