PMID: 9557728Apr 29, 1998Paper

Borna disease virus-induced neurological disorder in mice: infection of neonates results in immunopathology

Journal of Virology
W HallenslebenP Staeheli

Abstract

Borna disease virus (BDV) is a neurotropic nonsegmented negative-stranded RNA virus that persistently infects warm-blooded animals. In horses and other natural animal hosts, infections with BDV cause meningoencephalitis and behavioral disturbances. Experimental infection of adult mice takes a nonsymptomatic course, an observation previously believed to indicate that this animal species is not suitable for pathogenesis studies. We now demonstrate that BDV frequently induces severe neurological disease in infected newborn mice. Signs of neurological disease were first observed 4 to 6 weeks after intracerebral infection. They included a characteristic nonphysiological position of the hind limbs at an early stage of the disease and paraparesis at a later stage. Histological examination revealed large numbers of perivascular and meningeal inflammatory cells in brains of diseased mice and, unexpectedly, no increase in immunoreactivity to glial fibrillar acidic protein. The incidence and severity of BDV-induced disease varied dramatically among mouse strains. While only 13% of the infected C57BL/6 mice showed disease symptoms, which were mostly transient, more than 80% of the infected MRL mice developed severe neurological disorder. I...Continue Reading

References

Jul 1, 1992·Clinical and Experimental Immunology·H KannoM Kyogoku
Nov 11, 1991·Journal of Virology·K M CarboneG B Vogelsang
Jan 1, 1991·Archives of Virology·R RottK Frese
Dec 1, 1989·Biological Psychiatry·W DittrichK Schneider
Jun 16, 1989·Science·M R Capecchi
Feb 14, 1984·Biochemical and Biophysical Research Communications·F PanabièresJ M Blanchard
Jul 1, 1983·The Journal of General Virology·N HiranoH Ludwig
Oct 1, 1984·The Journal of General Virology·M KaoG Gosztonyi
Jun 1, 1995·Current Biology : CB·E P BrandonG S McKnight
Jul 1, 1994·Brain Pathology·L F Eng, R S Ghirnikar
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·T BrieseW I Lipkin
Jan 1, 1993·Journal of Virology·S A RubinK M Carbone
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·R P Junghans, C L Anderson
Jan 1, 1997·Archives of Virology·W HallenslebenP Staeheli

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Citations

Oct 10, 2008·Journal of Virology·Durdica CekinovićStipan Jonjić
Jul 28, 2019·Acta Neuropathologica·Friederike LiescheJürgen Schlegel
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·J HausmannP Staeheli
Oct 18, 2005·The Journal of General Virology·Malte SchwardtMartin Schwemmle
Apr 13, 2007·Journal of Virology·Urs SchneiderPeter Staeheli
May 28, 2010·Science Translational Medicine·Don GanemJoseph DeRisi
Sep 4, 2016·Virology Journal·Manon BourgChristiane Herden
Jul 4, 2001·Clinical Microbiology Reviews·K M Carbone
Mar 12, 2010·Journal of Virology·Peter StaeheliBernd Kaspers
Aug 10, 2007·Journal of Virology·Kirsten RichterPeter Staeheli
Jan 22, 2005·The Journal of General Virology·Jürgen HausmannPeter Staeheli
May 24, 2016·Animal Health Research Reviews·Ian TizardSusan Payne
Mar 6, 2010·Interdisciplinary Perspectives on Infectious Diseases·Marylou V Solbrig
Oct 20, 2007·The Journal of General Virology·Andreas AckermannPeter Staeheli
Feb 15, 2021·Journal of Digestive Diseases·Xing Yue WuPing Hong Zhou
Mar 10, 2001·Reviews in Medical Virology·I Jordan, W I Lipkin

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