Boron containing compounds promote the survival and the maintenance of pancreatic β-cells

Molecular Biology Reports
Safa AydınFikrettin Şahin

Abstract

Diabetes mellitus is worldwide disease. The life of diabetic patients are dependent on exogenous insulin. Pancreas or particularly islet transplantations are performed for reducing external insulin dependency. External substances are also used to protect the β-cells from the death or increase insulin secretion. In the current study, two different boron containing compounds (sodium pentaborate pentahydrate-NaB and boric acid-BA) were investigated for their effect on pancreatic cells in terms of pro-apoptotic and anti-apoptotic markers, genes related to insulin production mechanism, pancreatic development and glucose metabolism, some antioxidant enzymes, and genes for the initiation of diabetes, insulin secretion and antioxidant enzyme activities in vitro. The results revealed that boron containing compounds did not lead to apoptosis. On the contrary, they increased cell viability, antioxidant enzyme activities and the level of genes related to insulin production. Overall evaluation, data in the current study showed that boron containing compounds might be promising therapeutic agents for type 1 diabetes. However, additional investigations are strictly needed to elucidate molecular mechanisms of boron containing compounds.

References

Jul 27, 1979·Biochemical and Biophysical Research Communications·S P SpielbergJ D Schulman
Feb 17, 1996·Lancet·P DandonaT Nicotera
Mar 2, 1999·Biological Trace Element Research·P D Howe
Mar 2, 1999·Biological Trace Element Research·S SammanA P Verus
Apr 14, 1999·Cell Death and Differentiation·A G Porter, R U Jänicke
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·I V TurkoF Murad
Jan 25, 2002·Annals of the New York Academy of Sciences·J W Yoon, H S Jun
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Dec 10, 2003·Oncogene·Jordan S Fridman, Scott W Lowe
Nov 10, 2006·Critical Reviews in Food Science and Nutrition·Cristina Palacios
May 1, 2007·Diabetes Research and Clinical Practice·Seok Man Son
Feb 16, 2008·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Hasan TürkezAsuman Ozkan
Aug 30, 2008·Nature·Qiao ZhouDouglas A Melton
Apr 15, 2009·Genetics·Laura M McNamee, Michael H Brodsky
Aug 12, 2009·Biological Trace Element Research·Romulus Ion ScoreiDana Iordachescu
Sep 15, 2009·Trends in Endocrinology and Metabolism : TEM·R Paul Robertson
Dec 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Bernard Thorens, Mike Mueckler
Jul 14, 2010·Antioxidants & Redox Signaling·Xin Gen Lei, Marko Z Vatamaniuk
Aug 6, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sema S HakkiErdogan E Hakki
Oct 11, 2011·International Journal of Biological Macromolecules·Xiaoyun LuYali Zhang
Jan 26, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Wenhao ChenLawrence Chan
Jun 5, 2013·Cold Spring Harbor Perspectives in Biology·Amanda B ParrishSally Kornbluth
Jan 15, 2014·British Journal of Pharmacology·Elango BhakkiyalakshmiKunka Mohanram Ramkumar
Jul 27, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Forrest H Nielsen
Feb 1, 2015·Biological Trace Element Research·Hüseyin ApdikFikrettin Şahin
Dec 3, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Renata DessordiAnderson Marliere Navarro
Dec 17, 2016·Diabetes Care·UNKNOWN American Diabetes Association
Oct 12, 2017·Biological Trace Element Research·Selcen CakirZeynep Soyer Sarica
Nov 28, 2017·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Irem UluisikAhmet Koc
Mar 17, 2018·Biological Trace Element Research·Haseeb KhaliqPeng Ke-Mei
Sep 29, 2018·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Yessica López-CabreraMarvin A Soriano-Ursúa

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR
flow cytometry
Assay

Software Mentioned

BLAST
Primer
GraphPad
GraphPad Prism

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Advances in Nutrition
Forrest H Nielsen, Curtiss D Eckhert
Biological Trace Element Research
Haseeb KhaliqPeng Ke-Mei
© 2021 Meta ULC. All rights reserved